Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis
Brain-stem and cerebellar encephalitis without the conventional anti-Ma2 autoantibody developed in a man with a history of seminoma. Phage display was used to discover IgG antibody directed at kelch-like protein 11. The same antibody was detected in 12 other men included in an archival series.
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| Veröffentlicht in: | The New England journal of medicine 2019-07, Vol.381 (1), p.47-54 |
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| container_title | The New England journal of medicine |
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| creator | Mandel-Brehm, Caleigh Dubey, Divyanshu Kryzer, Thomas J O’Donovan, Brian D Tran, Baouyen Vazquez, Sara E Sample, Hannah A Zorn, Kelsey C Khan, Lillian M Bledsoe, Ian O McKeon, Andrew Pleasure, Samuel J Lennon, Vanda A DeRisi, Joseph L Wilson, Michael R Pittock, Sean J |
| description | Brain-stem and cerebellar encephalitis without the conventional anti-Ma2 autoantibody developed in a man with a history of seminoma. Phage display was used to discover IgG antibody directed at kelch-like protein 11. The same antibody was detected in 12 other men included in an archival series. |
| doi_str_mv | 10.1056/NEJMoa1816721 |
| format | Article |
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Phage display was used to discover IgG antibody directed at kelch-like protein 11. The same antibody was detected in 12 other men included in an archival series.</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1816721</identifier><identifier>PMID: 31269365</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Adult ; Aged ; Antibodies ; Antigens ; Ataxia ; Autoantibodies ; Autoantibodies - analysis ; Brain - immunology ; Carrier Proteins - immunology ; Case reports ; Cell Surface Display Techniques ; Encephalitis ; Encephalitis - epidemiology ; Encephalitis - immunology ; Epidemiology ; Hashimoto Disease - epidemiology ; Hashimoto Disease - immunology ; Humans ; Immunoassay ; Immunoglobulin G ; Immunoglobulins ; Male ; Middle Aged ; Minnesota - epidemiology ; Multiple sclerosis ; NMR ; Nuclear magnetic resonance ; Paraneoplastic Syndromes, Nervous System - immunology ; Patients ; Phage display ; Prevalence ; Proteins ; Seminoma ; Seminoma - complications ; Testicular Neoplasms - complications ; Tumors ; Vertigo</subject><ispartof>The New England journal of medicine, 2019-07, Vol.381 (1), p.47-54</ispartof><rights>Copyright © 2019 Massachusetts Medical Society. All rights reserved.</rights><rights>Copyright © 2019 Massachusetts Medical Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-c4c5b66a0a21bf043250a7ccc52ef0c503a1755b97d08588c1aad12bb470d6713</citedby><cites>FETCH-LOGICAL-c445t-c4c5b66a0a21bf043250a7ccc52ef0c503a1755b97d08588c1aad12bb470d6713</cites><orcidid>0000-0002-8705-5084</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1816721$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa1816721$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>230,314,776,780,881,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31269365$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mandel-Brehm, Caleigh</creatorcontrib><creatorcontrib>Dubey, Divyanshu</creatorcontrib><creatorcontrib>Kryzer, Thomas J</creatorcontrib><creatorcontrib>O’Donovan, Brian D</creatorcontrib><creatorcontrib>Tran, Baouyen</creatorcontrib><creatorcontrib>Vazquez, Sara E</creatorcontrib><creatorcontrib>Sample, Hannah A</creatorcontrib><creatorcontrib>Zorn, Kelsey C</creatorcontrib><creatorcontrib>Khan, Lillian M</creatorcontrib><creatorcontrib>Bledsoe, Ian O</creatorcontrib><creatorcontrib>McKeon, Andrew</creatorcontrib><creatorcontrib>Pleasure, Samuel J</creatorcontrib><creatorcontrib>Lennon, Vanda A</creatorcontrib><creatorcontrib>DeRisi, Joseph L</creatorcontrib><creatorcontrib>Wilson, Michael R</creatorcontrib><creatorcontrib>Pittock, Sean J</creatorcontrib><title>Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Brain-stem and cerebellar encephalitis without the conventional anti-Ma2 autoantibody developed in a man with a history of seminoma. Phage display was used to discover IgG antibody directed at kelch-like protein 11. The same antibody was detected in 12 other men included in an archival series.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>Ataxia</subject><subject>Autoantibodies</subject><subject>Autoantibodies - analysis</subject><subject>Brain - immunology</subject><subject>Carrier Proteins - immunology</subject><subject>Case reports</subject><subject>Cell Surface Display Techniques</subject><subject>Encephalitis</subject><subject>Encephalitis - epidemiology</subject><subject>Encephalitis - immunology</subject><subject>Epidemiology</subject><subject>Hashimoto Disease - epidemiology</subject><subject>Hashimoto Disease - immunology</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulins</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Minnesota - epidemiology</subject><subject>Multiple sclerosis</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Paraneoplastic Syndromes, Nervous System - immunology</subject><subject>Patients</subject><subject>Phage display</subject><subject>Prevalence</subject><subject>Proteins</subject><subject>Seminoma</subject><subject>Seminoma - complications</subject><subject>Testicular Neoplasms - complications</subject><subject>Tumors</subject><subject>Vertigo</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kd1LHDEUxUNR6mr72FcZEMGXqbnJJJl9EZZl_WhtK9g-hzuZrJt1JlmT2YL_fbOsFRW8hHsh-XG4J4eQL0C_AhXy9Ofs24-AUINUDD6QEQjOy6qicoeMKGV1Wakx3yP7KS1pLqjGH8keBybHXIoRuf1uO7MoO3dvi5sYBut8AVBM_OCa0Dqbinxxa3vnQ4_lJKVgHA62LW4wordh1WEanClm3tjVAjs3uPSJ7M6xS_bz0zwgf85nv6eX5fWvi6vp5Lo0VSWG3I1opESKDJo5rTgTFJUxRjA7p0ZQjqCEaMaqpbWoawOILbCmqRRtpQJ-QM62uqt109vWWD9E7PQquh7jow7o9OsX7xb6LvzVss4_wVQWOHkSiOFhbdOge5eM7bqNs3XSjIl8ai5ERo_eoMuwjj7b21CgOKu5zFS5pUwMKUU7f14GqN7EpV_FlfnDlw6e6f_5ZOB4C_R90t4u-3eE_gG8mpur</recordid><startdate>20190704</startdate><enddate>20190704</enddate><creator>Mandel-Brehm, Caleigh</creator><creator>Dubey, Divyanshu</creator><creator>Kryzer, Thomas J</creator><creator>O’Donovan, Brian D</creator><creator>Tran, Baouyen</creator><creator>Vazquez, Sara E</creator><creator>Sample, Hannah A</creator><creator>Zorn, Kelsey C</creator><creator>Khan, Lillian M</creator><creator>Bledsoe, Ian O</creator><creator>McKeon, Andrew</creator><creator>Pleasure, Samuel J</creator><creator>Lennon, Vanda A</creator><creator>DeRisi, Joseph L</creator><creator>Wilson, Michael R</creator><creator>Pittock, Sean J</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8705-5084</orcidid></search><sort><creationdate>20190704</creationdate><title>Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis</title><author>Mandel-Brehm, Caleigh ; Dubey, Divyanshu ; Kryzer, Thomas J ; O’Donovan, Brian D ; Tran, Baouyen ; Vazquez, Sara E ; Sample, Hannah A ; Zorn, Kelsey C ; Khan, Lillian M ; Bledsoe, Ian O ; McKeon, Andrew ; Pleasure, Samuel J ; Lennon, Vanda A ; DeRisi, Joseph L ; Wilson, Michael R ; Pittock, Sean J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-c4c5b66a0a21bf043250a7ccc52ef0c503a1755b97d08588c1aad12bb470d6713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibodies</topic><topic>Antigens</topic><topic>Ataxia</topic><topic>Autoantibodies</topic><topic>Autoantibodies - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mandel-Brehm, Caleigh</au><au>Dubey, Divyanshu</au><au>Kryzer, Thomas J</au><au>O’Donovan, Brian D</au><au>Tran, Baouyen</au><au>Vazquez, Sara E</au><au>Sample, Hannah A</au><au>Zorn, Kelsey C</au><au>Khan, Lillian M</au><au>Bledsoe, Ian O</au><au>McKeon, Andrew</au><au>Pleasure, Samuel J</au><au>Lennon, Vanda A</au><au>DeRisi, Joseph L</au><au>Wilson, Michael R</au><au>Pittock, Sean J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2019-07-04</date><risdate>2019</risdate><volume>381</volume><issue>1</issue><spage>47</spage><epage>54</epage><pages>47-54</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>Brain-stem and cerebellar encephalitis without the conventional anti-Ma2 autoantibody developed in a man with a history of seminoma. 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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; New England Journal of Medicine Current |
| subjects | Adult Aged Antibodies Antigens Ataxia Autoantibodies Autoantibodies - analysis Brain - immunology Carrier Proteins - immunology Case reports Cell Surface Display Techniques Encephalitis Encephalitis - epidemiology Encephalitis - immunology Epidemiology Hashimoto Disease - epidemiology Hashimoto Disease - immunology Humans Immunoassay Immunoglobulin G Immunoglobulins Male Middle Aged Minnesota - epidemiology Multiple sclerosis NMR Nuclear magnetic resonance Paraneoplastic Syndromes, Nervous System - immunology Patients Phage display Prevalence Proteins Seminoma Seminoma - complications Testicular Neoplasms - complications Tumors Vertigo |
| title | Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis |
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