Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis

Brain-stem and cerebellar encephalitis without the conventional anti-Ma2 autoantibody developed in a man with a history of seminoma. Phage display was used to discover IgG antibody directed at kelch-like protein 11. The same antibody was detected in 12 other men included in an archival series.

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Veröffentlicht in:	The New England journal of medicine 2019-07, Vol.381 (1), p.47-54
Hauptverfasser:	Mandel-Brehm, Caleigh, Dubey, Divyanshu, Kryzer, Thomas J, O’Donovan, Brian D, Tran, Baouyen, Vazquez, Sara E, Sample, Hannah A, Zorn, Kelsey C, Khan, Lillian M, Bledsoe, Ian O, McKeon, Andrew, Pleasure, Samuel J, Lennon, Vanda A, DeRisi, Joseph L, Wilson, Michael R, Pittock, Sean J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antibodies Antigens Ataxia Autoantibodies Autoantibodies - analysis Brain - immunology Carrier Proteins - immunology Case reports Cell Surface Display Techniques Encephalitis Encephalitis - epidemiology Encephalitis - immunology Epidemiology Hashimoto Disease - epidemiology Hashimoto Disease - immunology Humans Immunoassay Immunoglobulin G Immunoglobulins Male Middle Aged Minnesota - epidemiology Multiple sclerosis NMR Nuclear magnetic resonance Paraneoplastic Syndromes, Nervous System - immunology Patients Phage display Prevalence Proteins Seminoma Seminoma - complications Testicular Neoplasms - complications Tumors Vertigo
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Beschreibung
Zusammenfassung:	Brain-stem and cerebellar encephalitis without the conventional anti-Ma2 autoantibody developed in a man with a history of seminoma. Phage display was used to discover IgG antibody directed at kelch-like protein 11. The same antibody was detected in 12 other men included in an archival series.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1816721