Circulating Apolipoprotein L1 is associated with insulin resistance-induced abnormal lipid metabolism

Circulating ApolipoproteinL1 (ApoL1) is a component of pre-β-high-density lipoprotein (HDL), however little is known about the relationship of ApoL1 with cardiometabolic factors. Considering previous studies reporting the correlation of ApoL1 to triglyceride, we have hypothesized that ApoL1 associat...

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Veröffentlicht in:	Scientific reports 2019-10, Vol.9 (1), p.14869-11, Article 14869
Hauptverfasser:	Nishimura, Kenji, Murakami, Taichi, Sakurai, Toshihiro, Miyoshi, Masashi, Kurahashi, Kiyoe, Kishi, Seiji, Tamaki, Masanori, Tominaga, Tatsuya, Yoshida, Sumiko, Nagai, Kojiro, Abe, Hideharu, Hui, Shu-Ping, Kotani, Kazuhiko, Doi, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	692/308/575 692/699/2743/2099 82/1 82/16 Adult Apolipoprotein L1 - blood Apolipoprotein L1 - genetics Apolipoproteins Beta cells Body Mass Index Case-Control Studies Cholesterol Cholesterol, HDL - blood Cholesterol, LDL - blood Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - pathology Female Fractionation Gene Expression Hep G2 Cells High density lipoprotein Humanities and Social Sciences Humans Insulin Insulin - blood Insulin - genetics Insulin - pharmacology Insulin resistance Insulin Resistance - genetics Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - pathology Lipid metabolism Lipid Metabolism - genetics Low density lipoprotein Male Metabolic disorders Metabolic syndrome Metabolic Syndrome - blood Metabolic Syndrome - genetics Metabolic Syndrome - pathology multidisciplinary Science Science (multidisciplinary) Secretion Triglycerides - blood
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Zusammenfassung:	Circulating ApolipoproteinL1 (ApoL1) is a component of pre-β-high-density lipoprotein (HDL), however little is known about the relationship of ApoL1 with cardiometabolic factors. Considering previous studies reporting the correlation of ApoL1 to triglyceride, we have hypothesized that ApoL1 associates with insulin-related metabolism. The current study examined their associations in 126 non-diabetic subjects and 36 patients with type 2 diabetes (T2DM). Non-diabetic subjects demonstrated triglyceride (standardized coefficients [s.c.] = 0.204, p
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-019-51367-7