Effects of Pedunculopontine Tegmental Nucleus Lesions on Responding for Intravenous Heroin under Different Schedules of Reinforcement

The pedunculopontine tegmental nucleus (PPTg) is believed to play important roles in reward and learning. We examined the effect of PPTg lesions (0.5 microl of 0.1 M NMDA injected bilaterally over 10 min) on the learning of an operant response for opiate reward. In 14 adult male Long-Evans rats, bil...

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