Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study

Summary Background Extranodal natural killer T-cell lymphoma (NKTCL), nasal type, is a rare and aggressive malignancy that occurs predominantly in Asian and Latin American populations. Although Epstein-Barr virus infection is a known risk factor, other risk factors and the pathogenesis of NKTCL are...

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Veröffentlicht in:	The lancet oncology 2016-09, Vol.17 (9), p.1240-1247
Hauptverfasser:	Li, Zheng, PhD, Xia, Yi, MD, Feng, Li-Na, MD, Chen, Jie-Rong, BSc, Li, Hong-Min, MD, Cui, Jing, PhD, Cai, Qing-Qing, Prof, Sim, Kar Seng, MS, Nairismägi, Maarja-Liisa, PhD, Laurensia, Yurike, BSc, Meah, Wee Yang, BSc, Liu, Wen-Sheng, MMS, Guo, Yun-Miao, PhD, Chen, Li-Zhen, ADN, Feng, Qi-Sheng, BSc, Pang, Chi Pui, DPhil, Chen, Li Jia, PhD, Chew, Soo Hong, Prof, Ebstein, Richard P, Prof, Foo, Jia Nee, PhD, Liu, Jianjun, Prof, Ha, Jeslin, BSc, Khoo, Lay Poh, BSc, Chin, Suk Teng, BSc, Zeng, Yi-Xin, Prof, Aung, Tin, Prof, Chowbay, Balram, Prof, Diong, Colin Phipps, MD, Zhang, Fen, MD, Liu, Yan-Hui, MD, Tang, Tiffany, MD, Tao, Miriam, MD, Quek, Richard, MD, Mohamad, Farid, MD, Tan, Soo Yong, Prof, Teh, Bin Tean, Prof, Ng, Siok Bian, FRCPA, Chng, Wee Joo, Prof, Ong, Choon Kiat, PhD, Okada, Yukinori, PhD, Raychaudhuri, Soumya, PhD, Lim, Soon Thye, MD, Tan, Wen, Prof, Peng, Rou-Jun, MD, Khor, Chiea Chuen, PhD, Bei, Jin-Xin, Prof
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antigen presentation Biomarkers, Tumor - genetics Cancer Case-Control Studies China Chromosome 6 Education Epstein-Barr virus Female Follow-Up Studies Gene mapping Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Genomes Haplotypes Hematology, Oncology and Palliative Medicine Hepatitis Histocompatibility antigen HLA Humans Linkage disequilibrium Lymphocytes T Lymphoma Lymphoma, Extranodal NK-T-Cell - genetics Lymphoma, Extranodal NK-T-Cell - pathology Major histocompatibility complex Male Malignancy Medical research Middle Aged Natural killer cells Neoplasm Staging Pathogenesis Peptides Polymorphism, Single Nucleotide - genetics Prognosis Risk Factors Single-nucleotide polymorphism Studies T cell receptors T-cell lymphoma Young Adult
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Zusammenfassung:	Summary Background Extranodal natural killer T-cell lymphoma (NKTCL), nasal type, is a rare and aggressive malignancy that occurs predominantly in Asian and Latin American populations. Although Epstein-Barr virus infection is a known risk factor, other risk factors and the pathogenesis of NKTCL are not well understood. We aimed to identify common genetic variants affecting individual risk of NKTCL. Methods We did a genome-wide association study of 189 patients with extranodal NKTCL, nasal type (WHO classification criteria; cases) and 957 controls from Guangdong province, southern China. We validated our findings in four independent case-control series, including 75 cases from Guangdong province and 296 controls from Hong Kong, 65 cases and 983 controls from Guangdong province, 125 cases and 1110 controls from Beijing (northern China), and 60 cases and 2476 controls from Singapore. We used imputation and conditional logistic regression analyses to fine-map the associations. We also did a meta-analysis of the replication series and of the entire dataset. Findings Associations exceeding the genome-wide significance threshold (p
ISSN:	1470-2045 1474-5488
DOI:	10.1016/S1470-2045(16)30148-6