Genome-wide association studies of brain imaging phenotypes in UK Biobank

The genetic architecture of brain structure and function is largely unknown. To investigate this, we carried out genome-wide association studies of 3,144 functional and structural brain imaging phenotypes from UK Biobank (discovery dataset 8,428 subjects). Here we show that many of these phenotypes...

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Veröffentlicht in:	Nature (London) 2018-10, Vol.562 (7726), p.210-216
Hauptverfasser:	Elliott, Lloyd T., Sharp, Kevin, Alfaro-Almagro, Fidel, Shi, Sinan, Miller, Karla L., Douaud, Gwenaëlle, Marchini, Jonathan, Smith, Stephen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	45/43 59 59/57 631/208/205/2138 631/208/480 631/378/2583 Aging Aging - genetics Alzheimer's disease Architecture Automation Axonogenesis Behavior disorders Biological Specimen Banks Brain Brain - anatomy & histology Brain - diagnostic imaging Brain - growth & development Brain - pathology Brain architecture Brain research Chromosomes Consortia Datasets as Topic Developmental plasticity Epidermal growth factor Epidermal Growth Factor - genetics Epidermal growth factors Extracellular Matrix Female Functional anatomy Gene loci Genes Genetic aspects Genetic polymorphisms Genome-Wide Association Study Genomes Genomics Growth factors Heredity Humanities and Social Sciences Humans Imaging Iron Iron - metabolism Iron transport Lesions Magnetic permeability Magnetic susceptibility Male Medical imaging Mental disorders multidisciplinary Neurodevelopmental disorders Neuroimaging Neurological diseases Neuronal Plasticity - genetics NMR Nuclear magnetic resonance Phenotype Phenotypes Polymorphism, Single Nucleotide - genetics Putamen - anatomy & histology Putamen - metabolism Schizophrenia Science Science (multidisciplinary) Signal transduction Signal Transduction - genetics Single nucleotide polymorphisms Single-nucleotide polymorphism Structure Structure-function relationships Substantia alba United Kingdom White Matter - anatomy & histology White Matter - metabolism White Matter - pathology
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Beschreibung
Zusammenfassung:	The genetic architecture of brain structure and function is largely unknown. To investigate this, we carried out genome-wide association studies of 3,144 functional and structural brain imaging phenotypes from UK Biobank (discovery dataset 8,428 subjects). Here we show that many of these phenotypes are heritable. We identify 148 clusters of associations between single nucleotide polymorphisms and imaging phenotypes that replicate at P
ISSN:	0028-0836 1476-4687
DOI:	10.1038/s41586-018-0571-7