Serum pigment epithelium-derived factor: Relationships with cardiovascular events, renal dysfunction, and mortality in the Veterans Affairs Diabetes Trial (VADT) cohort

Serum pigment epithelium-derived factor: Relationships with cardiovascular events, renal dysfunction, and mortality in the Veterans Affairs Diabetes Trial (VADT) cohort

To determine if serum pigment epithelium-derived factor (PEDF) levels predict cardiovascular events, renal dysfunction and mortality in the Veterans Affairs Diabetes Study (VADT). PEDF was evaluated in relation to subsequent cardiovascular outcomes, mortality, and renal dysfunction (defined as urina...

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Veröffentlicht in:Journal of diabetes and its complications 2019-10, Vol.33 (10), p.107410-107410, Article 107410
Hauptverfasser: Hunt, Kelly J., Jenkins, Alicia J., Fu, Dongxu, Stevens, Danielle, Ma, Jian-xing, Klein, Richard L., Azar, Madona, Zhang, Sarah X., Lopes-Virella, Maria F., Lyons, Timothy J.
Format: Artikel
Sprache:eng
Schlagworte:
Albuminuria - blood
Biomarkers - blood
Blood pressure
Body mass index
Cardiovascular
Cardiovascular disease
Cardiovascular Diseases - blood
Cardiovascular Diseases - epidemiology
Cholesterol
Cohort
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - mortality
Diabetic Angiopathies - blood
Diabetic Angiopathies - epidemiology
Diabetic Nephropathies - blood
Eye Proteins - blood
Female
Glomerular Filtration Rate
Humans
Kidney diseases
Male
Middle Aged
Mortality
Nerve Growth Factors - blood
PEDF
Renal
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - epidemiology
Risk factor
Serpins - blood
Triglycerides
Veterans
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Beschreibung
Zusammenfassung:To determine if serum pigment epithelium-derived factor (PEDF) levels predict cardiovascular events, renal dysfunction and mortality in the Veterans Affairs Diabetes Study (VADT). PEDF was evaluated in relation to subsequent cardiovascular outcomes, mortality, and renal dysfunction (defined as urinary albumin creatinine ratio (ACR) ≥300 mg/g), or chronic kidney disease (CKD) stages 3 (eGFR
ISSN:1056-8727
1873-460X
DOI:10.1016/j.jdiacomp.2019.107410