A novel GPR55-mediated satiety signal in the oval Bed Nucleus of the Stria Terminalis
Nestled within feeding circuits, the oval (ov) region of the Bed Nucleus of the Stria Terminalis (BNST) may be critical for monitoring energy balance through changes in synaptic strength. Here we report that bidirectional plasticity at ovBNST GABA synapses was tightly linked to the caloric state of...
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| Veröffentlicht in: | Neuropsychopharmacology (New York, N.Y.) N.Y.), 2019-06, Vol.44 (7), p.1274-1283 |
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| creator | Hawken, E R Normandeau, C P Gardner Gregory, J Cécyre, B Bouchard, J-F Mackie, K Dumont, É C |
| description | Nestled within feeding circuits, the oval (ov) region of the Bed Nucleus of the Stria Terminalis (BNST) may be critical for monitoring energy balance through changes in synaptic strength. Here we report that bidirectional plasticity at ovBNST GABA synapses was tightly linked to the caloric state of male rats, seesawing between long-term potentiation (iLTP, fed) and depression (iLTD, food restricted). L-α-lysophosphatidylinositol (LPI) acting on GPR55 receptors and 2-arachidonoylglycerol (2-AG) through CB1R were respectively responsible for fed (iLTP) and food restricted (iLTD) states. Thus, we have characterized a potential gating mechanism within the ovBNST that may signal metabolic state within the rat brain feeding circuitry. |
| doi_str_mv | 10.1038/s41386-018-0309-0 |
| format | Article |
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Here we report that bidirectional plasticity at ovBNST GABA synapses was tightly linked to the caloric state of male rats, seesawing between long-term potentiation (iLTP, fed) and depression (iLTD, food restricted). L-α-lysophosphatidylinositol (LPI) acting on GPR55 receptors and 2-arachidonoylglycerol (2-AG) through CB1R were respectively responsible for fed (iLTP) and food restricted (iLTD) states. Thus, we have characterized a potential gating mechanism within the ovBNST that may signal metabolic state within the rat brain feeding circuitry.</description><identifier>ISSN: 0893-133X</identifier><identifier>EISSN: 1740-634X</identifier><identifier>DOI: 10.1038/s41386-018-0309-0</identifier><identifier>PMID: 30647449</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>2-Arachidonoylglycerol ; Animals ; Channel gating ; Dietary restrictions ; Energy balance ; Feeding ; gamma-Aminobutyric Acid - physiology ; Gene Knockout Techniques ; Inhibitory Postsynaptic Potentials ; Long-term potentiation ; Male ; Mice, Inbred C57BL ; Neuronal Plasticity ; Rats, Long-Evans ; Receptor, Cannabinoid, CB1 - genetics ; Receptor, Cannabinoid, CB1 - physiology ; Receptors, Cannabinoid - genetics ; Receptors, Cannabinoid - physiology ; Receptors, G-Protein-Coupled - genetics ; Receptors, G-Protein-Coupled - physiology ; Rodents ; Satiety ; Satiety Response - physiology ; Septal Nuclei - physiology ; Stria terminalis ; Synapses ; Synapses - physiology ; Synaptic plasticity ; Synaptic strength</subject><ispartof>Neuropsychopharmacology (New York, N.Y.), 2019-06, Vol.44 (7), p.1274-1283</ispartof><rights>Copyright Nature Publishing Group Jun 2019</rights><rights>American College of Neuropsychopharmacology 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-64127561d8a09cd69f761f8f8ea03785c9e84854ca3ff87edbef22a0ffef81843</citedby><cites>FETCH-LOGICAL-c394t-64127561d8a09cd69f761f8f8ea03785c9e84854ca3ff87edbef22a0ffef81843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785105/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785105/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30647449$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hawken, E R</creatorcontrib><creatorcontrib>Normandeau, C P</creatorcontrib><creatorcontrib>Gardner Gregory, J</creatorcontrib><creatorcontrib>Cécyre, B</creatorcontrib><creatorcontrib>Bouchard, J-F</creatorcontrib><creatorcontrib>Mackie, K</creatorcontrib><creatorcontrib>Dumont, É C</creatorcontrib><title>A novel GPR55-mediated satiety signal in the oval Bed Nucleus of the Stria Terminalis</title><title>Neuropsychopharmacology (New York, N.Y.)</title><addtitle>Neuropsychopharmacology</addtitle><description>Nestled within feeding circuits, the oval (ov) region of the Bed Nucleus of the Stria Terminalis (BNST) may be critical for monitoring energy balance through changes in synaptic strength. Here we report that bidirectional plasticity at ovBNST GABA synapses was tightly linked to the caloric state of male rats, seesawing between long-term potentiation (iLTP, fed) and depression (iLTD, food restricted). L-α-lysophosphatidylinositol (LPI) acting on GPR55 receptors and 2-arachidonoylglycerol (2-AG) through CB1R were respectively responsible for fed (iLTP) and food restricted (iLTD) states. Thus, we have characterized a potential gating mechanism within the ovBNST that may signal metabolic state within the rat brain feeding circuitry.</description><subject>2-Arachidonoylglycerol</subject><subject>Animals</subject><subject>Channel gating</subject><subject>Dietary restrictions</subject><subject>Energy balance</subject><subject>Feeding</subject><subject>gamma-Aminobutyric Acid - physiology</subject><subject>Gene Knockout Techniques</subject><subject>Inhibitory Postsynaptic Potentials</subject><subject>Long-term potentiation</subject><subject>Male</subject><subject>Mice, Inbred C57BL</subject><subject>Neuronal Plasticity</subject><subject>Rats, Long-Evans</subject><subject>Receptor, Cannabinoid, CB1 - genetics</subject><subject>Receptor, Cannabinoid, CB1 - physiology</subject><subject>Receptors, Cannabinoid - genetics</subject><subject>Receptors, Cannabinoid - physiology</subject><subject>Receptors, G-Protein-Coupled - genetics</subject><subject>Receptors, G-Protein-Coupled - physiology</subject><subject>Rodents</subject><subject>Satiety</subject><subject>Satiety Response - physiology</subject><subject>Septal Nuclei - physiology</subject><subject>Stria terminalis</subject><subject>Synapses</subject><subject>Synapses - physiology</subject><subject>Synaptic plasticity</subject><subject>Synaptic strength</subject><issn>0893-133X</issn><issn>1740-634X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpVUU1LAzEQDaLYWv0BXiTgOZpsstnkItSiVSgq2kJvId1N2pTtria7hf57U1uLXmaGmTdvPh4AlwTfEEzFbWCECo4wEQhTLBE-Al2SMYw4ZdNj0MVCUkQonXbAWQhLjEmacXEKOhRzljEmu2DSh1W9NiUcvr2nKVqZwunGFDDoxplmA4ObV7qEroLNwsB6HeP7WH5p89K0Adb2J__ReKfh2PiVi2gXzsGJ1WUwF3vfA5PHh_HgCY1eh8-D_gjlVLIGcUaSLOWkEBrLvODSZpxYYYXRmGYizaURTKQs19RakZliZmySaGytsYIIRnvgbsf72c7i6rmpGq9L9endSvuNqrVT_yuVW6h5vVY8shOcRoLrPYGvv1oTGrWsWx9vCCpJkpQQKbmIKLJD5b4OwRt7mECw2iqhdkqoqITaKhFND1z9Xe3Q8ft6-g2fQIRm</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Hawken, E R</creator><creator>Normandeau, C P</creator><creator>Gardner Gregory, J</creator><creator>Cécyre, B</creator><creator>Bouchard, J-F</creator><creator>Mackie, K</creator><creator>Dumont, É C</creator><general>Nature Publishing Group</general><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20190601</creationdate><title>A novel GPR55-mediated satiety signal in the oval Bed Nucleus of the Stria Terminalis</title><author>Hawken, E R ; Normandeau, C P ; Gardner Gregory, J ; Cécyre, B ; Bouchard, J-F ; Mackie, K ; Dumont, É C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-64127561d8a09cd69f761f8f8ea03785c9e84854ca3ff87edbef22a0ffef81843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>2-Arachidonoylglycerol</topic><topic>Animals</topic><topic>Channel gating</topic><topic>Dietary restrictions</topic><topic>Energy balance</topic><topic>Feeding</topic><topic>gamma-Aminobutyric Acid - physiology</topic><topic>Gene Knockout Techniques</topic><topic>Inhibitory Postsynaptic Potentials</topic><topic>Long-term potentiation</topic><topic>Male</topic><topic>Mice, Inbred C57BL</topic><topic>Neuronal Plasticity</topic><topic>Rats, Long-Evans</topic><topic>Receptor, Cannabinoid, CB1 - genetics</topic><topic>Receptor, Cannabinoid, CB1 - physiology</topic><topic>Receptors, Cannabinoid - genetics</topic><topic>Receptors, Cannabinoid - physiology</topic><topic>Receptors, G-Protein-Coupled - genetics</topic><topic>Receptors, G-Protein-Coupled - physiology</topic><topic>Rodents</topic><topic>Satiety</topic><topic>Satiety Response - physiology</topic><topic>Septal Nuclei - physiology</topic><topic>Stria terminalis</topic><topic>Synapses</topic><topic>Synapses - physiology</topic><topic>Synaptic plasticity</topic><topic>Synaptic strength</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hawken, E R</creatorcontrib><creatorcontrib>Normandeau, C P</creatorcontrib><creatorcontrib>Gardner Gregory, J</creatorcontrib><creatorcontrib>Cécyre, B</creatorcontrib><creatorcontrib>Bouchard, J-F</creatorcontrib><creatorcontrib>Mackie, K</creatorcontrib><creatorcontrib>Dumont, É C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuropsychopharmacology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hawken, E R</au><au>Normandeau, C P</au><au>Gardner Gregory, J</au><au>Cécyre, B</au><au>Bouchard, J-F</au><au>Mackie, K</au><au>Dumont, É C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel GPR55-mediated satiety signal in the oval Bed Nucleus of the Stria Terminalis</atitle><jtitle>Neuropsychopharmacology (New York, N.Y.)</jtitle><addtitle>Neuropsychopharmacology</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>44</volume><issue>7</issue><spage>1274</spage><epage>1283</epage><pages>1274-1283</pages><issn>0893-133X</issn><eissn>1740-634X</eissn><abstract>Nestled within feeding circuits, the oval (ov) region of the Bed Nucleus of the Stria Terminalis (BNST) may be critical for monitoring energy balance through changes in synaptic strength. Here we report that bidirectional plasticity at ovBNST GABA synapses was tightly linked to the caloric state of male rats, seesawing between long-term potentiation (iLTP, fed) and depression (iLTD, food restricted). L-α-lysophosphatidylinositol (LPI) acting on GPR55 receptors and 2-arachidonoylglycerol (2-AG) through CB1R were respectively responsible for fed (iLTP) and food restricted (iLTD) states. Thus, we have characterized a potential gating mechanism within the ovBNST that may signal metabolic state within the rat brain feeding circuitry.</abstract><cop>England</cop><pub>Nature Publishing Group</pub><pmid>30647449</pmid><doi>10.1038/s41386-018-0309-0</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0893-133X |
| ispartof | Neuropsychopharmacology (New York, N.Y.), 2019-06, Vol.44 (7), p.1274-1283 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | 2-Arachidonoylglycerol Animals Channel gating Dietary restrictions Energy balance Feeding gamma-Aminobutyric Acid - physiology Gene Knockout Techniques Inhibitory Postsynaptic Potentials Long-term potentiation Male Mice, Inbred C57BL Neuronal Plasticity Rats, Long-Evans Receptor, Cannabinoid, CB1 - genetics Receptor, Cannabinoid, CB1 - physiology Receptors, Cannabinoid - genetics Receptors, Cannabinoid - physiology Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - physiology Rodents Satiety Satiety Response - physiology Septal Nuclei - physiology Stria terminalis Synapses Synapses - physiology Synaptic plasticity Synaptic strength |
| title | A novel GPR55-mediated satiety signal in the oval Bed Nucleus of the Stria Terminalis |
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