A novel GPR55-mediated satiety signal in the oval Bed Nucleus of the Stria Terminalis

Nestled within feeding circuits, the oval (ov) region of the Bed Nucleus of the Stria Terminalis (BNST) may be critical for monitoring energy balance through changes in synaptic strength. Here we report that bidirectional plasticity at ovBNST GABA synapses was tightly linked to the caloric state of...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2019-06, Vol.44 (7), p.1274-1283
Hauptverfasser:	Hawken, E R, Normandeau, C P, Gardner Gregory, J, Cécyre, B, Bouchard, J-F, Mackie, K, Dumont, É C
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Arachidonoylglycerol Animals Channel gating Dietary restrictions Energy balance Feeding gamma-Aminobutyric Acid - physiology Gene Knockout Techniques Inhibitory Postsynaptic Potentials Long-term potentiation Male Mice, Inbred C57BL Neuronal Plasticity Rats, Long-Evans Receptor, Cannabinoid, CB1 - genetics Receptor, Cannabinoid, CB1 - physiology Receptors, Cannabinoid - genetics Receptors, Cannabinoid - physiology Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - physiology Rodents Satiety Satiety Response - physiology Septal Nuclei - physiology Stria terminalis Synapses Synapses - physiology Synaptic plasticity Synaptic strength
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Zusammenfassung:	Nestled within feeding circuits, the oval (ov) region of the Bed Nucleus of the Stria Terminalis (BNST) may be critical for monitoring energy balance through changes in synaptic strength. Here we report that bidirectional plasticity at ovBNST GABA synapses was tightly linked to the caloric state of male rats, seesawing between long-term potentiation (iLTP, fed) and depression (iLTD, food restricted). L-α-lysophosphatidylinositol (LPI) acting on GPR55 receptors and 2-arachidonoylglycerol (2-AG) through CB1R were respectively responsible for fed (iLTP) and food restricted (iLTD) states. Thus, we have characterized a potential gating mechanism within the ovBNST that may signal metabolic state within the rat brain feeding circuitry.
ISSN:	0893-133X 1740-634X
DOI:	10.1038/s41386-018-0309-0