Functional Attributes Discriminating Mechano-Insensitive and Mechano-Responsive C Nociceptors in Human Skin

Functional Attributes Discriminating Mechano-Insensitive and Mechano-Responsive C Nociceptors in Human Skin

Microneurography was used in healthy human subjects to record action potentials from unmyelinated nerve fibers (C units) in cutaneous fascicles of the peroneal nerve. Activity-dependent slowing (n = 96) and transcutaneous electrical thresholds (n = 67) were determined. Eight units were sympathetic e...

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Veröffentlicht in:The Journal of neuroscience 1999-11, Vol.19 (22), p.10184-10190
Hauptverfasser: Weidner, C, Schmelz, M, Schmidt, R, Hansson, B, Handwerker, H. O, Torebjork, H. E
Format: Artikel
Sprache:eng
Schlagworte:
Adult
capsaicin
Discrimination (Psychology)
Efferent Pathways - physiology
Electric Stimulation
Female
Humans
Male
microneurography
Nerve Fibers - physiology
Neural Conduction
Nociceptors - physiology
Pain Threshold
peroneal nerve
Peroneal Nerve - physiology
Reaction Time
Sensory Thresholds
Skin - innervation
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Zusammenfassung:Microneurography was used in healthy human subjects to record action potentials from unmyelinated nerve fibers (C units) in cutaneous fascicles of the peroneal nerve. Activity-dependent slowing (n = 96) and transcutaneous electrical thresholds (n = 67) were determined. Eight units were sympathetic efferents according to their responses to sympathetic reflex provocations. Mechano-heat-responsive C units (CMH) (n = 56) had thresholds to von Frey hair stimulation
ISSN:0270-6474
1529-2401
DOI:10.1523/jneurosci.19-22-10184.1999