Challenges With Left Ventricular Functional Parameters: The Pediatric Heart Network Normal Echocardiogram Database

The reliability of left ventricular (LV) systolic functional indices calculated from blinded echocardiographic measurements of LV size has not been tested in a large cohort of healthy children. The objective of this study was to estimate interobserver variability in standard measurements of LV size...

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Veröffentlicht in:	Journal of the American Society of Echocardiography 2019-10, Vol.32 (10), p.1331-1338.e1
Hauptverfasser:	Minich, L. LuAnn, Altmann, Karen, Camarda, Joseph, Cohen, Meryl S., Colan, Steven D., Dragulescu, Andreea, Frommelt, Michele A., Johnson, Tiffanie R., Kovalchin, John P., Lin, Lina, Mahgerefteh, Joseph, Nutting, Arni, Pearson, Gail D., Sachdeva, Ritu, Statile, Christopher J., Tierney, E. Seda, Lopez, Leo, Burns, Kristin, Stylianou, Mario, Mahony, Lynn, Chen, Shan, Gongwer, Russell, Granger, Suzanne, Keosaian, Julia, Langley, Susanne, Mansolf, Tammi, Moine, Stephanie, Morrison, Andrew, Nelson, Katelyn, Ni, Brenda, Ortiz, Janet, Pucillo, Michelle, Stark, Paul, Trachtenberg, Felicia, Winrich, Barbara, McCrindle, Brian, Radojewski, Elizabeth, Mital, Seema, Walter, Patricia, Slorach, Cameron, Newburger, Jane, Levine, Jami, Paridon, Stephen, Cohen, Meryl, Goldberg, David, Morrison, Tonia, Chowdhury, Shahryar, Infinger, Patricia, LuAnn Minich, L., Truong, Dongngan T., Lambert, Linda M., Shearrow, Marian E., Stanton, Belva, Goldberg, Caren, Welch, Suzanne, Cnota, James F., Ash, Kathleen, Sticka, Joshua, Payne, Mark, Cordes, Timothy, Swan, Liz, Friedman, Heather S., Clark, Laurie J., Penny, Daniel, Pignatelli, Ricardo, Lai, Wyman, Anderson, Brett, Thankavel, Poonam Punjwani, Carron, Hollie, Ginde, Salil, Frommelt, Michele, Markham, Larry, Parra, David A., Soslow, Jonathan H., Young, Luciana, Van't Hof, Kathleen, Lewin, Mark, Lester, Joel, Bhat, Aarti H., Payne, Amy, Srivastava, Shubhika, Lytrivi, Irene, Ko, Helen, Balem, Kelly Ann, Sable, Craig, Stelter, Jessica, Artman, Michael, Rao, Anu, Johnson, Julie, Krischer, Jeffrey P., Kugler, John, Driscoll, David, Hunsberger, Sally, Taylor, Holly
Format:	Artikel
Sprache:	eng
Schlagworte:	Echocardiography Ejection fraction Left ventricle Pediatric Shortening fraction
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Zusammenfassung:	The reliability of left ventricular (LV) systolic functional indices calculated from blinded echocardiographic measurements of LV size has not been tested in a large cohort of healthy children. The objective of this study was to estimate interobserver variability in standard measurements of LV size and systolic function in children with normal cardiac anatomy and qualitatively normal function. The Pediatric Heart Network Normal Echocardiogram Database collected normal echocardiograms from healthy children ≤18 years old distributed equally by age, gender, and race. A core lab used two-dimensional echocardiograms to measure LV dimensions from which a separate data coordinating center calculated LV volumes and systolic functional indices. To evaluate interobserver variability, two independent expert pediatric echocardiographic observers remeasured LV dimensions on a subset of studies, while blinded to calculated volumes and functional indices. Of 3,215 subjects with measurable images, 552 (17%) had a calculated LV shortening fraction (SF)
ISSN:	0894-7317 1097-6795
DOI:	10.1016/j.echo.2019.05.025