Identification of the pyranonigrin A biosynthetic gene cluster by genome mining in Penicillium thymicola IBT 5891

Identification of the pyranonigrin A biosynthetic gene cluster by genome mining in Penicillium thymicola IBT 5891

Significance A polyketide synthase and nonribosomal peptide synthetase hybrid gene cluster from the genome of Penicillium thymicola was identified through genome mining. Heterologous expression of this cluster leads to the production of pyranonigrin A. A series of experiments established that only f...

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Veröffentlicht in:AIChE journal 2018-12, Vol.64 (12), p.4182-4186
Hauptverfasser: Tang, Man‐Cheng, Zou, Yi, Yee, Danielle, Tang, Yi
Format: Artikel
Sprache:eng
Schlagworte:
biosynthesis
Gene expression
genome mining
Genomes
heterologous expression
Organic chemistry
Penicillium
Polyketide synthase
pyranonigrin A
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Zusammenfassung:Significance A polyketide synthase and nonribosomal peptide synthetase hybrid gene cluster from the genome of Penicillium thymicola was identified through genome mining. Heterologous expression of this cluster leads to the production of pyranonigrin A. A series of experiments established that only four genes are sufficient to biosynthesize pyranonigrin A. Based on the results from the current study, a biosynthetic pathway of pyranonigrin A is proposed. © 2018 American Institute of Chemical Engineers AIChE J, 64: 4182–4186, 2018
ISSN:0001-1541
1547-5905
DOI:10.1002/aic.16324