A systematic review and meta‐analysis of clinical predictors of lithium response in bipolar disorder

Objective To determine clinical predictors of lithium response in bipolar disorder. Methods Systematic review of studies examining clinical predictors of lithium response was conducted. Meta‐analyses were performed when ≥2 studies examined the same potential predictor. Results A total of 71 studies,...

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Veröffentlicht in:	Acta psychiatrica Scandinavica 2019-08, Vol.140 (2), p.94-115
Hauptverfasser:	Hui, T. P., Kandola, A., Shen, L., Lewis, G., Osborn, D. P. J., Geddes, J. R., Hayes, J. F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Affective disorders Antimanic Agents - therapeutic use Bipolar disorder Bipolar Disorder - drug therapy Bipolar Disorder - epidemiology Bipolar Disorder - psychology Body Mass Index clinical aspects Female Hospitalization - statistics & numerical data Humans Lithium Lithium - therapeutic use Lithium Compounds - therapeutic use Male Mental depression Meta-analysis Observational Studies as Topic Predictive Value of Tests Psychosis Randomized Controlled Trials as Topic Systematic review Systematic Review / Meta‐Analysis Treatment Outcome
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Zusammenfassung:	Objective To determine clinical predictors of lithium response in bipolar disorder. Methods Systematic review of studies examining clinical predictors of lithium response was conducted. Meta‐analyses were performed when ≥2 studies examined the same potential predictor. Results A total of 71 studies, including over 12 000 patients, identified six predictors of good response: mania‐depression‐interval sequence [odds ratio (OR): 4.27; 95% CI: 2.61, 6.97; P
ISSN:	0001-690X 1600-0447
DOI:	10.1111/acps.13062