Clinical Analysis of Propofol, Etomidate and an Admixture of Etomidate and Propofol for Induction of General Anaesthesia
To compare the clinical outcome following induction of general anaesthesia with intravenous (IV) injection of propofol (P), etomidate (E) or a 50% admixture of propofol and etomidate (PE). In this prospective, randomised, double-blind controlled study, patients 18-60 years of age who were undergoing...
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| Veröffentlicht in: | Turkish Journal of Anaesthesiology and Reanimation 2019-10, Vol.47 (5), p.382-386 |
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| creator | Rathore, Vikram Singh Singh, Shalendra Taank, Priya Khandelwal, Ankur Kaushal, Ashutosh |
| description | To compare the clinical outcome following induction of general anaesthesia with intravenous (IV) injection of propofol (P), etomidate (E) or a 50% admixture of propofol and etomidate (PE).
In this prospective, randomised, double-blind controlled study, patients 18-60 years of age who were undergoing elective surgery with general anaesthesia were randomised to receive either propofol 2.5 mg kg
IV (group P; n=30), etomidate 0.3 mg kg
IV (group E; n=30) or an admixture of etomidate 0.2 mg kg
IV and propofol 1 mg kg
IV (group PE; n=30) as the induction agent. The haemodynamic response was first recorded at baseline, then at 1 minute following administration the study drug, and 1, 3, 5, 10, 20, 30 and 40 minutes following intubation. Perioperative symptoms such as myoclonus, pain upon injection and/or vomiting upon induction as well as postoperative nausea were recorded.
We observed a decrease in systemic haemodynamics from baseline following induction in group P compared to groups E and PE (p |
| doi_str_mv | 10.5152/TJAR.2019.53806 |
| format | Article |
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In this prospective, randomised, double-blind controlled study, patients 18-60 years of age who were undergoing elective surgery with general anaesthesia were randomised to receive either propofol 2.5 mg kg
IV (group P; n=30), etomidate 0.3 mg kg
IV (group E; n=30) or an admixture of etomidate 0.2 mg kg
IV and propofol 1 mg kg
IV (group PE; n=30) as the induction agent. The haemodynamic response was first recorded at baseline, then at 1 minute following administration the study drug, and 1, 3, 5, 10, 20, 30 and 40 minutes following intubation. Perioperative symptoms such as myoclonus, pain upon injection and/or vomiting upon induction as well as postoperative nausea were recorded.
We observed a decrease in systemic haemodynamics from baseline following induction in group P compared to groups E and PE (p<0.05). Incidence of myoclonus was reduced from 76.6% in group E to 6.6% in group PE (p<0.001). There was also a reduction in reported pain upon injection in group PE compared to group P (p<0.001). Although we found no statistically significant difference between the three groups when assessing postoperative nausea and vomiting, these symptoms were more prevalent in groups E and PE than in group P.
Using an admixture of etomidate and propofol as the induction agent reduced the incidence of side effects observed with use of either drug alone such as pain upon injection, myoclonus and haemodynamic instability.</description><identifier>ISSN: 2667-677X</identifier><identifier>ISSN: 2149-0937</identifier><identifier>EISSN: 2667-6370</identifier><identifier>DOI: 10.5152/TJAR.2019.53806</identifier><identifier>PMID: 31572988</identifier><language>eng</language><publisher>Turkey: AVES</publisher><subject>Anesthesia ; Anesthesiology ; Critical care ; Drug dosages ; Etomidate ; Intubation ; Medical research ; Myoclonus ; Nausea ; Original ; Pain ; Pain management ; Phenols (Class of compounds) ; Propofol ; Surgery ; Vecuronium ; Vomiting</subject><ispartof>Turkish Journal of Anaesthesiology and Reanimation, 2019-10, Vol.47 (5), p.382-386</ispartof><rights>Copyright 2019 by Turkish Anaesthesiology and Intensive Care Society.</rights><rights>COPYRIGHT 2019 AVES</rights><rights>2019. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at http://jtaics.org/?p=aims</rights><rights>Copyright 2019 by Turkish Anaesthesiology and Intensive Care Society 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-4678a2fa56dbcacdeed3868280d4c71ec2f270b1e460b264e3e45af7af8884223</citedby><orcidid>0000-0002-7915-9158 ; 0000-0002-1112-3431 ; 0000-0002-4167-5376 ; 0000-0001-5374-1097 ; 0000-0001-8552-7861</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756308/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756308/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31572988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rathore, Vikram Singh</creatorcontrib><creatorcontrib>Singh, Shalendra</creatorcontrib><creatorcontrib>Taank, Priya</creatorcontrib><creatorcontrib>Khandelwal, Ankur</creatorcontrib><creatorcontrib>Kaushal, Ashutosh</creatorcontrib><creatorcontrib>155 Base Hospital Tezpur, Assam, India</creatorcontrib><creatorcontrib>Department of Anaesthesiology and Critical Care, Armed Forces Medical College, Pune, India</creatorcontrib><creatorcontrib>Department of Neuroanaesthesiology and Critical Care, All India Institute of Medical Sciences (AIIMS), New Delhi, India</creatorcontrib><creatorcontrib>Department of Ophthalmology, Command Hospital (SC), Pune, India</creatorcontrib><title>Clinical Analysis of Propofol, Etomidate and an Admixture of Etomidate and Propofol for Induction of General Anaesthesia</title><title>Turkish Journal of Anaesthesiology and Reanimation</title><addtitle>Turk J Anaesthesiol Reanim</addtitle><description>To compare the clinical outcome following induction of general anaesthesia with intravenous (IV) injection of propofol (P), etomidate (E) or a 50% admixture of propofol and etomidate (PE).
In this prospective, randomised, double-blind controlled study, patients 18-60 years of age who were undergoing elective surgery with general anaesthesia were randomised to receive either propofol 2.5 mg kg
IV (group P; n=30), etomidate 0.3 mg kg
IV (group E; n=30) or an admixture of etomidate 0.2 mg kg
IV and propofol 1 mg kg
IV (group PE; n=30) as the induction agent. The haemodynamic response was first recorded at baseline, then at 1 minute following administration the study drug, and 1, 3, 5, 10, 20, 30 and 40 minutes following intubation. Perioperative symptoms such as myoclonus, pain upon injection and/or vomiting upon induction as well as postoperative nausea were recorded.
We observed a decrease in systemic haemodynamics from baseline following induction in group P compared to groups E and PE (p<0.05). Incidence of myoclonus was reduced from 76.6% in group E to 6.6% in group PE (p<0.001). There was also a reduction in reported pain upon injection in group PE compared to group P (p<0.001). Although we found no statistically significant difference between the three groups when assessing postoperative nausea and vomiting, these symptoms were more prevalent in groups E and PE than in group P.
Using an admixture of etomidate and propofol as the induction agent reduced the incidence of side effects observed with use of either drug alone such as pain upon injection, myoclonus and haemodynamic instability.</description><subject>Anesthesia</subject><subject>Anesthesiology</subject><subject>Critical care</subject><subject>Drug dosages</subject><subject>Etomidate</subject><subject>Intubation</subject><subject>Medical research</subject><subject>Myoclonus</subject><subject>Nausea</subject><subject>Original</subject><subject>Pain</subject><subject>Pain management</subject><subject>Phenols (Class of compounds)</subject><subject>Propofol</subject><subject>Surgery</subject><subject>Vecuronium</subject><subject>Vomiting</subject><issn>2667-677X</issn><issn>2149-0937</issn><issn>2667-6370</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptUlFrHCEQltLShDTPfSsLfe1dXHXVfSksR5omBFpKCn0TV8fEsqtX3S3Jv6-by6U9KCIOzvd9M6MfQm9rvG7qhpzdXHXf1gTX7bqhEvMX6JhwLlacCvxyHwvx4wid5ux73DBGCpq-Rke0bgRppTxG95vBB2_0UHVBDw_Z5yq66muK2-ji8KE6n-LorZ6g0sGWXXV29PfTnGDBHWb3rMrFVF0GO5vJx7DgLiBA2tWAPN1B9voNeuX0kOH06TxB3z-d32w-r66_XFxuuuuVYVJOK8aF1MTphtveaGMBLJVcEoktM6IGQxwRuK-BcdwTzoACa7QT2kkpy7z0BH3c6W7nfgRrIEylE7VNftTpQUXt1WEm-Dt1G38rLhpOsSwC758EUvw1l_bVzzin8lhZEdLWbVvqs7-oWz2A8sHFImZGn43qOKaMS455Qa3_gyrLwuhNDOB8uT8gnO0IJsWcE7jnxmusFhOoxQRqMYF6NEFhvPt33mf8_svpH6ECras</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Rathore, Vikram Singh</creator><creator>Singh, Shalendra</creator><creator>Taank, Priya</creator><creator>Khandelwal, Ankur</creator><creator>Kaushal, Ashutosh</creator><general>AVES</general><general>Aves Yayincilik Ltd. 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In this prospective, randomised, double-blind controlled study, patients 18-60 years of age who were undergoing elective surgery with general anaesthesia were randomised to receive either propofol 2.5 mg kg
IV (group P; n=30), etomidate 0.3 mg kg
IV (group E; n=30) or an admixture of etomidate 0.2 mg kg
IV and propofol 1 mg kg
IV (group PE; n=30) as the induction agent. The haemodynamic response was first recorded at baseline, then at 1 minute following administration the study drug, and 1, 3, 5, 10, 20, 30 and 40 minutes following intubation. Perioperative symptoms such as myoclonus, pain upon injection and/or vomiting upon induction as well as postoperative nausea were recorded.
We observed a decrease in systemic haemodynamics from baseline following induction in group P compared to groups E and PE (p<0.05). Incidence of myoclonus was reduced from 76.6% in group E to 6.6% in group PE (p<0.001). There was also a reduction in reported pain upon injection in group PE compared to group P (p<0.001). Although we found no statistically significant difference between the three groups when assessing postoperative nausea and vomiting, these symptoms were more prevalent in groups E and PE than in group P.
Using an admixture of etomidate and propofol as the induction agent reduced the incidence of side effects observed with use of either drug alone such as pain upon injection, myoclonus and haemodynamic instability.</abstract><cop>Turkey</cop><pub>AVES</pub><pmid>31572988</pmid><doi>10.5152/TJAR.2019.53806</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-7915-9158</orcidid><orcidid>https://orcid.org/0000-0002-1112-3431</orcidid><orcidid>https://orcid.org/0000-0002-4167-5376</orcidid><orcidid>https://orcid.org/0000-0001-5374-1097</orcidid><orcidid>https://orcid.org/0000-0001-8552-7861</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Turkish Journal of Anaesthesiology and Reanimation, 2019-10, Vol.47 (5), p.382-386 |
| issn | 2667-677X 2149-0937 2667-6370 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6756308 |
| source | DOAJ Directory of Open Access Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Anesthesia Anesthesiology Critical care Drug dosages Etomidate Intubation Medical research Myoclonus Nausea Original Pain Pain management Phenols (Class of compounds) Propofol Surgery Vecuronium Vomiting |
| title | Clinical Analysis of Propofol, Etomidate and an Admixture of Etomidate and Propofol for Induction of General Anaesthesia |
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