Genomic and transcriptomic landscapes of Epstein-Barr virus in extranodal natural killer T-cell lymphoma

Extranodal natural killer T-cell lymphoma (nasal type; NKTCL) is an aggressive malignancy strongly associated with Epstein-Barr virus (EBV) infection. However, the role of EBV in NKTCL development is unclear, largely due to the lack of information about EBV genome and transcriptome in NKTCL. Here, u...

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Veröffentlicht in:	Leukemia 2019-06, Vol.33 (6), p.1451-1462
Hauptverfasser:	Peng, Rou-Jun, Han, Bo-Wei, Cai, Qing-Qing, Zuo, Xiao-Yu, Xia, Tao, Chen, Jie-Rong, Feng, Li-Na, Lim, Jing Quan, Chen, Shu-Wei, Zeng, Mu-Sheng, Guo, Yun-Miao, Li, Bo, Xia, Xiao-Jun, Xia, Yi, Laurensia, Yurike, Chia, Burton Kuan Hui, Huang, Hui-Qiang, Young, Ken He, Lim, Soon Thye, Ong, Choon Kiat, Zeng, Yi-Xin, Bei, Jin-Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	38/23 45/91 631/208/69 631/67/1858 Adult Cancer Research Clonal deletion Critical Care Medicine Disruption Epitopes Epstein-Barr virus Epstein-Barr Virus Infections - complications Epstein-Barr Virus Infections - genetics Epstein-Barr Virus Infections - virology Female Gene expression Gene Expression Regulation, Viral Gene sequencing Genetic aspects Genetic transcription Genome, Viral Genomes Genomics - methods Hematology Herpesvirus 4, Human - genetics Humans Intensive Internal Medicine Killer cells Lymphocytes T Lymphoma Lymphoma, Extranodal NK-T-Cell - epidemiology Lymphoma, Extranodal NK-T-Cell - genetics Lymphoma, Extranodal NK-T-Cell - virology Male Malignancy Medicine Medicine & Public Health miRNA Mutation Natural killer cells Natural Killer T-Cells - metabolism Natural Killer T-Cells - virology Next-generation sequencing Oncology Phylogeny T cell lymphoma Transcription Transcriptome Tumorigenesis Viral Proteins - genetics Viruses Whole Genome Sequencing
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Zusammenfassung:	Extranodal natural killer T-cell lymphoma (nasal type; NKTCL) is an aggressive malignancy strongly associated with Epstein-Barr virus (EBV) infection. However, the role of EBV in NKTCL development is unclear, largely due to the lack of information about EBV genome and transcriptome in NKTCL. Here, using high-throughput sequencing, we obtained whole genome ( n = 27) and transcriptome datasets ( n = 18) of EBV derived from NKTCL tumor biopsies. We assembled 27 EBV genomes and detected an average of 1,152 single nucleotide variants and 44.8 indels (
ISSN:	0887-6924 1476-5551
DOI:	10.1038/s41375-018-0324-5