Yunnan Baiyao reduces hospital-acquired pressure ulcers via suppressing virulence gene expression and biofilm formation of Staphylococcus aureus

Yunnan Baiyao (YB) as a kind of famous Chinese herbal medicine, possessed hemostatic, invigorating the circulation of blood, and anti-inflammatory effects. Identifying strategies to protect patients at risk for hospital-acquired pressure ulcers (HAPU) is essential. Herein, our results showed that YB treatment can effectively reduce the acne wound area and improve efficacy in a comparative study of 60 cases HAPU patients with positive of acne wound pathogens. Furthermore, YB inhibited HIa expression and suppressed accessory gene regulator ( ) system controlled by regulatory RNA II and RNA III molecule using pALC1740, pALC1742 and pALC1743 . strain linked to gfp reporter gene. Moreover, YB downregulated mRNA expression and inhibited coagulase activity by RT-PCR slide and tube coagulase test. Additionally, YB downregulated , , , and -1 mRNA expression to suppress enterotoxin and tsst-1 secretion and adhesion function related genes , , and mRNA expression. Taken together, the data suggest that YB may reduce HAPU via suppressing virulence gene expression and biofilm formation of