Low-frequency variants at the CYP2C9 locus among Puerto Rican patients on warfarin: in silico predictions of functionality and conservation

Low-frequency variants at the CYP2C9 locus among Puerto Rican patients on warfarin: in silico predictions of functionality and conservation

Perform predictions of functional consequences of variants identified by next-generation sequencing in Puerto Ricans. Identified low-frequency variants (minor allele frequencies

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Bibliographische Detailangaben
Veröffentlicht in:Pharmacogenomics 2019-08, Vol.20 (12), p.891-902
Hauptverfasser: Claudio-Campos, Karla, Moneró-Paredes, Mariangeli, Hernández, Eliud, Renta, Jessicca, Duconge, Jorge
Format: Artikel
Sprache:eng
Schlagworte:
Anticoagulants
Anticoagulants - adverse effects
Cytochrome
Cytochrome P-450 CYP2C9 - genetics
Deoxyribonucleic acid
Design
DNA
Drug dosages
Enzymes
Female
Gene frequency
Gene Frequency - genetics
Genes
Genotype
Heme
Hispanic Americans - genetics
Hispanic people
Humans
Ligands
Male
Metabolism
Molecular modelling
Next-generation sequencing
Patients
Pharmacogenetics - methods
Polymorphism
Polymorphism, Single Nucleotide - genetics
Retrospective Studies
Software
Warfarin
Warfarin - adverse effects
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Beschreibung
Zusammenfassung:Perform predictions of functional consequences of variants identified by next-generation sequencing in Puerto Ricans. Identified low-frequency variants (minor allele frequencies
ISSN:1462-2416
1744-8042
DOI:10.2217/pgs-2019-0051