MCP-1 promotes detrimental cardiac physiology, pulmonary edema, and death in the cpk model of polycystic kidney disease

Polycystic kidney disease (PKD) is characterized by slowly expanding renal cysts that damage the kidney, typically resulting in renal failure by the fifth decade. The most common cause of death in these patients, however, is cardiovascular disease. Expanding cysts in PKD induce chronic kidney injury...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2019-08, Vol.317 (2), p.F343-F360
Hauptverfasser:	Salah, Sally M, Meisenheimer, James D, Rao, Reena, Peda, Jacqueline D, Wallace, Darren P, Foster, Dawson, Li, Xiaogang, Li, Xiaoyan, Zhou, Xia, Vallejo, Julian A, Wacker, Michael J, Fields, Timothy A, Swenson-Fields, Katherine I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Arrhythmias, Cardiac - metabolism Arrhythmias, Cardiac - pathology Arrhythmias, Cardiac - physiopathology Cardiomegaly - metabolism Cardiomegaly - pathology Cardiomegaly - physiopathology Cardiovascular diseases Cells, Cultured Chemokine CCL2 - deficiency Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Chemokines Cysts Death Disease Models, Animal Disease Progression Edema EKG Fibrosis Heart rate Humans Hypertrophy Inflammation Mediators - metabolism Kidney - metabolism Kidney - pathology Kidney - physiopathology Kidney diseases Lung - metabolism Lung - pathology Lung - physiopathology Macrophages Macrophages - metabolism Macrophages - pathology Membrane Proteins - genetics Mice, Inbred C57BL Mice, Knockout Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Monocytes Myocardium - metabolism Myocardium - pathology Polycystic kidney Polycystic Kidney Diseases - metabolism Polycystic Kidney Diseases - pathology Polycystic Kidney Diseases - physiopathology Pulmonary Edema - metabolism Pulmonary Edema - pathology Pulmonary Edema - physiopathology Pulmonary Edema - prevention & control Renal failure Respiratory function Time Factors
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