Production of 5α-Reduced Neurosteroids Is Developmentally Regulated and Shapes GABAA Miniature IPSCs in Lamina II of the Spinal Cord

Production of 5α-Reduced Neurosteroids Is Developmentally Regulated and Shapes GABAA Miniature IPSCs in Lamina II of the Spinal Cord

In lamina II of the spinal dorsal horn, synaptic inhibition mediated by ionotropic GABA A and glycine receptors contributes to the integration of peripheral nociceptive messages. Whole-cell patch-clamp recordings were performed from lamina II neurons in spinal cord slices to study the properties of...

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Veröffentlicht in:The Journal of neuroscience 2004-01, Vol.24 (4), p.907-915
Hauptverfasser: Keller, A. Florence, Breton, Jean-Didier, Schlichter, Rémy, Poisbeau, Pierrick
Format: Artikel
Sprache:eng
Schlagworte:
Cellular/Molecular
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Zusammenfassung:In lamina II of the spinal dorsal horn, synaptic inhibition mediated by ionotropic GABA A and glycine receptors contributes to the integration of peripheral nociceptive messages. Whole-cell patch-clamp recordings were performed from lamina II neurons in spinal cord slices to study the properties of miniature IPSCs (mIPSCs) mediated by activation of GABA A and glycine receptors in immature (
ISSN:0270-6474
1529-2401
DOI:10.1523/JNEUROSCI.4642-03.2004