Genome‐wide association study identifies loci associated with liability to alcohol and drug dependence that is associated with variability in reward‐related ventral striatum activity in African‐ and European‐Americans

Genetic influences on alcohol and drug dependence partially overlap, however, specific loci underlying this overlap remain unclear. We conducted a genome‐wide association study (GWAS) of a phenotype representing alcohol or illicit drug dependence (ANYDEP) among 7291 European‐Americans (EA; 2927 case...

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Veröffentlicht in:	Genes, brain and behavior brain and behavior, 2019-07, Vol.18 (6), p.e12580-n/a
Hauptverfasser:	Wetherill, Leah, Lai, Dongbing, Johnson, Emma C., Anokhin, Andrey, Bauer, Lance, Bucholz, Kathleen K., Dick, Danielle M., Hariri, Ahmad R., Hesselbrock, Victor, Kamarajan, Chella, Kramer, John, Kuperman, Samuel, Meyers, Jacquelyn L., Nurnberger, John I., Schuckit, Marc, Scott, Denise M., Taylor, Robert E., Tischfield, Jay, Porjesz, Bernice, Goate, Alison M., Edenberg, Howard J., Foroud, Tatiana, Bogdan, Ryan, Agrawal, Arpana
Format:	Artikel
Sprache:	eng
Schlagworte:	African‐American Alcohol alcohol dependence Alcoholic beverages Alcoholism Black or African American - genetics Chromosome 1 Chromosome 5 Chromosome deletion Chromosomes, Human, Pair 13 - genetics Chromosomes, Human, Pair 3 - genetics Drug abuse Drug dependence European‐American fMRI Genetic Loci Genetic markers genetics Genome-wide association studies Genomes GWAS Hemostasis heritability Humans Insertion Neostriatum neural reward Phenotype Phenotypes Polymorphism, Single Nucleotide Reinforcement Reward Signal transduction Single-nucleotide polymorphism Substance use Substance-Related Disorders - ethnology Substance-Related Disorders - genetics Substance-Related Disorders - physiopathology Transduction ventral striatum Ventral Striatum - physiopathology White People - genetics
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Zusammenfassung:	Genetic influences on alcohol and drug dependence partially overlap, however, specific loci underlying this overlap remain unclear. We conducted a genome‐wide association study (GWAS) of a phenotype representing alcohol or illicit drug dependence (ANYDEP) among 7291 European‐Americans (EA; 2927 cases) and 3132 African‐Americans (AA: 1315 cases) participating in the family‐based Collaborative Study on the Genetics of Alcoholism. ANYDEP was heritable (h 2 in EA = 0.60, AA = 0.37). The AA GWAS identified three regions with genome‐wide significant (GWS; P
ISSN:	1601-1848 1601-183X
DOI:	10.1111/gbb.12580