Compartmentalization of the GABAB receptor signaling complex is required for presynaptic inhibition at hippocampal synapses

Presynaptic inhibition via G-protein-coupled receptors (GPCRs) and voltage-gated Ca(2+) channels constitutes a widespread regulatory mechanism of synaptic strength. Yet, the mechanism of intermolecular coupling underlying GPCR-mediated signaling at central synapses remains unresolved. Using FRET spe...

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Veröffentlicht in:	The Journal of neuroscience 2011-08, Vol.31 (35), p.12523-12532
Hauptverfasser:	Laviv, Tal, Vertkin, Irena, Berdichevsky, Yevgeny, Fogel, Hilla, Riven, Inbal, Bettler, Bernhard, Slesinger, Paul A, Slutsky, Inna
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Baclofen - pharmacology Calcium - metabolism Calcium Channels, N-Type - genetics Calcium Channels, N-Type - metabolism Cyclic AMP - metabolism Electric Stimulation GABA Antagonists - pharmacology GABA-B Receptor Agonists - pharmacology GTP-Binding Protein beta Subunits - genetics GTP-Binding Protein beta Subunits - metabolism GTP-Binding Protein gamma Subunits - genetics GTP-Binding Protein gamma Subunits - metabolism Hippocampus - cytology Luminescent Proteins - genetics Mice Mice, Inbred BALB C Mice, Knockout Microscopy, Confocal Mutation - genetics Neural Inhibition - drug effects Neural Inhibition - physiology Organophosphorus Compounds - pharmacology Pertussis Toxin - pharmacology Picrotoxin - pharmacology Presynaptic Terminals - drug effects Presynaptic Terminals - physiology Rats Rats, Wistar Receptors, GABA-B - deficiency Receptors, GABA-B - metabolism Signal Transduction - genetics Signal Transduction - physiology Spectroscopy, Fourier Transform Infrared - methods Synapses - drug effects Synapses - physiology Synaptic Vesicles - metabolism
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Zusammenfassung:	Presynaptic inhibition via G-protein-coupled receptors (GPCRs) and voltage-gated Ca(2+) channels constitutes a widespread regulatory mechanism of synaptic strength. Yet, the mechanism of intermolecular coupling underlying GPCR-mediated signaling at central synapses remains unresolved. Using FRET spectroscopy, we provide evidence for formation of spatially restricted (
ISSN:	0270-6474 1529-2401
DOI:	10.1523/JNEUROSCI.1527-11.2011