Pericytes: The Brain’s Very First Responders?

Infection can negatively impact brain functions. Here, Duan et al. (2018) show that specific PDGFRβ-expressing cell subtypes of the neurovascular unit release the chemokine CCL2 rapidly after systemic infection, leading to increased neural excitability. Infection can negatively impact brain function...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2018-10, Vol.100 (1), p.11-13
Hauptverfasser:	Rafalski, Victoria A., Merlini, Mario, Akassoglou, Katerina
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial infections Brain Chemokine CCL2 Chemokines Cytokines Disseminated infection Emergency Responders Excitability Fibroblasts Gene expression Humans Infections Inflammation Monocyte chemoattractant protein 1 Motility Neurons Pericytes Proteins Receptor, Platelet-Derived Growth Factor beta Rodents Studies Viral infections
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Zusammenfassung:	Infection can negatively impact brain functions. Here, Duan et al. (2018) show that specific PDGFRβ-expressing cell subtypes of the neurovascular unit release the chemokine CCL2 rapidly after systemic infection, leading to increased neural excitability. Infection can negatively impact brain functions. Here, Duan et al. show that specific PDGFRβ-expressing cell subtypes of the neurovascular unit release the chemokine CCL2 rapidly after systemic infection, leading to increased neural excitability.
ISSN:	0896-6273 1097-4199
DOI:	10.1016/j.neuron.2018.09.033