Vitamin D status during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study in a multiracial cohort

Vitamin D status during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study in a multiracial cohort

Aim To prospectively and longitudinally investigate vitamin D status during early to mid‐pregnancy in relation to gestational diabetes mellitus (GDM) risk. Methods In a nested case‐control study of 107 GDM cases and 214 controls within the Fetal Growth Studies‐Singleton Cohort, plasma levels of 25‐h...

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Veröffentlicht in:Diabetes, obesity & metabolism obesity & metabolism, 2019-08, Vol.21 (8), p.1895-1905
Hauptverfasser: Xia, Jin, Song, Yiqing, Rawal, Shristi, Wu, Jing, Hinkle, Stefanie N., Tsai, Michael Y., Zhang, Cuilin
Format: Artikel
Sprache:eng
Schlagworte:
25-Hydroxyvitamin D 2 - blood
Adult
Calcifediol - blood
Case-Control Studies
Diabetes
Diabetes mellitus
Diabetes, Gestational - epidemiology
Diabetes, Gestational - ethnology
Diabetes, Gestational - etiology
Female
Fetuses
Gestation
Gestational diabetes
Health risk assessment
Humans
Logistic Models
Longitudinal Studies
Observational studies
observational study
Odds Ratio
Plasma levels
population study
Pregnancy
Pregnancy Complications - blood
Pregnancy Complications - ethnology
Pregnancy Complications - etiology
Pregnancy Trimester, First - blood
Regression analysis
Risk Factors
Vitamin D
Vitamin D Deficiency - blood
Vitamin D Deficiency - complications
Vitamin D Deficiency - ethnology
Vitamin D-Binding Protein - blood
Vitamin deficiency
Young Adult
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Zusammenfassung:Aim To prospectively and longitudinally investigate vitamin D status during early to mid‐pregnancy in relation to gestational diabetes mellitus (GDM) risk. Methods In a nested case‐control study of 107 GDM cases and 214 controls within the Fetal Growth Studies‐Singleton Cohort, plasma levels of 25‐hydroxyvitamin D2 and D3 (25(OH)D) and vitamin D binding protein were measured at gestational weeks 10 to 14, 15 to 26, 23 to 31, and 33 to 39; we further calculated total, free, and bioavailable 25(OH)D. Conditional logistic regression models and linear mixed‐effects models were used. Results We observed a threshold effect for the relation of vitamin D biomarkers with GDM risk. Vitamin D deficiency (
ISSN:1462-8902
1463-1326
DOI:10.1111/dom.13748