Beyond proteome diversity: alternative splicing as a regulator of neuronal transcript dynamics

Highlights • Function of alternative splicing in neurons is not restricted to diversification of protein families. • Alternative splicing targets mRNA populations to additional RNA metabolism pathways. • Alternative splicing regulates spatio-temporal expression of neuronal proteins. • Alternative sp...

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Veröffentlicht in:	Current opinion in neurobiology 2017-08, Vol.45, p.162-168
Hauptverfasser:	Mauger, Oriane, Scheiffele, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing - physiology Animals Central Nervous System - pathology Central Nervous System - physiology Gene Expression Regulation Genetic Variation Humans Neurology Neurons - physiology Proteome - genetics Psychiatry
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Zusammenfassung:	Highlights • Function of alternative splicing in neurons is not restricted to diversification of protein families. • Alternative splicing targets mRNA populations to additional RNA metabolism pathways. • Alternative splicing regulates spatio-temporal expression of neuronal proteins. • Alternative splicing directs cell-type specific transcriptomes. • Alternative splicing controls rapid modification of neuronal transcriptomes.
ISSN:	0959-4388 1873-6882
DOI:	10.1016/j.conb.2017.05.012