Association of elevated serumfree light chains with chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis
Chronic lymphocytic leukemia (CLL) and its precursor, monoclonal B-cell lymphocytosis (MBL), are heritable. Serumfree light-chain (sFLC) measures are a prognostic factor for CLL, but their role in susceptibility to CLL is not clear. We investigated differences between sFLC measurements in pre-treatm...
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Veröffentlicht in: | Blood cancer journal (New York) 2019-08, Vol.9 (8), p.59-8, Article 59 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Chronic lymphocytic leukemia (CLL) and its precursor, monoclonal B-cell lymphocytosis (MBL), are heritable. Serumfree light-chain (sFLC) measures are a prognostic factor for CLL, but their role in susceptibility to CLL is not clear. We investigated differences between sFLC measurements in pre-treatment serum from five groups to inform the association of sFLC with familial and sporadic CLL: (1) familial CLL (
n
= 154), (2) sporadic CLL (
n
= 302), (3) familial MBL (
n
= 87), (4) unaffected first-degree relatives from CLL/MBL families (
n
= 263), and (5) reference population (
n
= 15,396). The percent of individuals having elevated monoclonal and polyclonal sFLCs was compared using age-stratified and age- and sex-adjusted logistic regression models. In age groups >50 years, monoclonal sFLC elevations were increased in sporadic and familial CLL cases compared to the reference population (
p
’s 0.05). Unaffected relatives and MBL cases from CLL/MBL families, ages >60 years, showed elevated monoclonal sFLC, compared to the reference population (
p
’s |
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ISSN: | 2044-5385 2044-5385 |
DOI: | 10.1038/s41408-019-0220-x |