Testosterone in Men With Chronic Hepatitis C Infection and After Hepatitis C Viral Clearance
Hepatitis C virus (HCV) and hepatic dysfunction are associated with low total and free testosterone (TT and FT) and high sex hormone-binding globulin (SHBG). However, little is known about changes in testosterone following successful HCV treatment. We evaluated testosterone levels and the prevalence...
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Veröffentlicht in: | Clinical infectious diseases 2019-08, Vol.69 (4), p.571-576 |
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Sprache: | eng |
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Zusammenfassung: | Hepatitis C virus (HCV) and hepatic dysfunction are associated with low total and free testosterone (TT and FT) and high sex hormone-binding globulin (SHBG). However, little is known about changes in testosterone following successful HCV treatment.
We evaluated testosterone levels and the prevalence of low testosterone in a cohort of 327 men with chronic HCV infection (human immunodeficiency virus [HIV] coinfection = 150) and in a subset of 85 men with testosterone levels obtained pre-HCV treatment and after sustained virologic response (SVR). Median follow-up was 36 months.
Participants with active HCV at baseline had higher TT (P < .0001) and SHBG (P < .0001) compared with participants who had achieved SVR, whereas FT did not differ. Low TT ( |
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ISSN: | 1058-4838 1537-6591 |
DOI: | 10.1093/cid/ciy965 |