Glucose Inhibition Persists in Hypothalamic Neurons Lacking Tandem-Pore K+ Channels

Glucose sensing by hypothalamic neurons triggers adaptive metabolic and behavioral responses. In orexin neurons, extracellular glucose activates a leak K(+) current promoting electrical activity inhibition. Sensitivity to external acidification and halothane, and resistance to ruthenium red designat...

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Veröffentlicht in:	The Journal of neuroscience 2009-02, Vol.29 (8), p.2528-2533
Hauptverfasser:	Guyon, Alice, Tardy, Magalie P, Rovere, Carole, Nahon, Jean-Louis, Barhanin, Jacques, Lesage, Florian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Barium Barium - pharmacology Biochemistry, Molecular Biology Brief Communications Glucose Glucose - pharmacology Hydrogen-Ion Concentration Hypothalamus Hypothalamus - cytology In Vitro Techniques Intracellular Signaling Peptides and Proteins Intracellular Signaling Peptides and Proteins - metabolism Life Sciences Male Membrane Potentials Membrane Potentials - drug effects Membrane Potentials - genetics Mice Mice, Inbred C57BL Mice, Knockout Nerve Tissue Proteins Nerve Tissue Proteins - deficiency Neural Inhibition Neural Inhibition - drug effects Neural Inhibition - physiology Neurons Neurons - drug effects Neurons - physiology Neurons and Cognition Neuropeptides Neuropeptides - metabolism Orexins Patch-Clamp Techniques Patch-Clamp Techniques - methods Potassium Channels Potassium Channels - deficiency Potassium Channels, Tandem Pore Domain Potassium Channels, Tandem Pore Domain - classification Potassium Channels, Tandem Pore Domain - deficiency Sweetening Agents Sweetening Agents - pharmacology
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