High-fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett’s Esophagus via IL8 and Alterations to the Gut Microbiome

High-fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett’s Esophagus via IL8 and Alterations to the Gut Microbiome

In an inflammation induced mouse model of esophageal tumor development a diet rich in fat is leading to accelerated tumor growth in part caused by changes in the gut microbiome which induces an accelerated inflammatory microenvironment.

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Veröffentlicht in:Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2019-04, Vol.157 (2), p.492-506.e2
Hauptverfasser: Münch, Natasha Stephens, Fang, Hsin-Yu, Ingermann, Jonas, Maurer, H. Carlo, Anand, Akanksha, Kellner, Victoria, Sahm, Vincenz, Wiethaler, Maria, Baumeister, Theresa, Wein, Frederik, Einwächter, Henrik, Bolze, Florian, Klingenspor, Martin, Haller, Dirk, Kavanagh, Maria, Lysaght, Joanne, Friedman, Richard, Dannenberg, Andrew J., Pollak, Michael, Holt, Peter R, Muthupalani, Sureshkumar, Fox, James G., Whary, Mark T., Lee, Yoomi, Ren, Tony Y., Elliot, Rachael, Fitzgerald, Rebecca, Steiger, Katja, Schmid, Roland M., Wang, Timothy C., Quante, Michael
Format: Artikel
Sprache:eng
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Zusammenfassung:In an inflammation induced mouse model of esophageal tumor development a diet rich in fat is leading to accelerated tumor growth in part caused by changes in the gut microbiome which induces an accelerated inflammatory microenvironment.
ISSN:0016-5085
1528-0012
DOI:10.1053/j.gastro.2019.04.013