Mouse T cells express a neurotransmitter-receptor signature that is quantitatively modulated in a subset- and activation-dependent manner
•Peripheral T cells transcribe less than 30 of the 185 annotated Neurotransmitter receptor genes.•More than half (14–16) of these NR transcripts are found in all subsets constituting a “core” signature.•We identify a narrow subset of
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| Veröffentlicht in: | Brain, behavior, and immunity behavior, and immunity, 2019-08, Vol.80, p.275-285 |
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| container_title | Brain, behavior, and immunity |
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| creator | Rosenberg, Kenneth M. Singh, Nevil J. |
| description | •Peripheral T cells transcribe less than 30 of the 185 annotated Neurotransmitter receptor genes.•More than half (14–16) of these NR transcripts are found in all subsets constituting a “core” signature.•We identify a narrow subset of |
| doi_str_mv | 10.1016/j.bbi.2019.04.002 |
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Neurotransmitters are known to modulate the course of an immune response by targeting cells in both the innate and adaptive immune systems. Increasing evidence suggests that T cells, by expressing specific neurotransmitter receptors (NR) are directly regulated by them, leading to altered activation and skewed differentiation of the adaptive immune response. Given that gene expression in T cells changes in lineage- and activation-dependent fashion, it is expected that sensitivity to neurotransmitters may also vary along these lines. Here we generate an important resource for further analysis of this tier of immunoregulation, by identifying the distinct profile of NR transcripts that are expressed by peripheral T cells in mice, at different states of activation and differentiation. We find that only about 15% of the total annotated NR genes are transcribed in these T cells and most of them do not change in different subsets of T cells (CD8, CD4 – Naïve vs Memory vs Treg), or even when T cells migrate to different tissues. We suggest that the T cell-expressed NRs, found across all these subsets identifies a core, constitutive NR signature for the T cell lineage. In contrast, a very limited number (<2) of NRs were observed to mark each of the post-activation T cell states, suggesting that very specific neurotransmitter signals are available to modulate T cell responses in vivo in these subsets.</description><identifier>ISSN: 0889-1591</identifier><identifier>ISSN: 1090-2139</identifier><identifier>EISSN: 1090-2139</identifier><identifier>DOI: 10.1016/j.bbi.2019.04.002</identifier><identifier>PMID: 30953766</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Female ; Lymphocyte Activation ; Male ; Mice, Inbred C57BL ; Receptors, Neurotransmitter - genetics ; Receptors, Neurotransmitter - metabolism ; T-Lymphocyte Subsets - metabolism ; T-Lymphocytes - metabolism</subject><ispartof>Brain, behavior, and immunity, 2019-08, Vol.80, p.275-285</ispartof><rights>2019 Elsevier Inc.</rights><rights>Copyright © 2019 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-c5007f5f7051ca11c6cbc516d4776f7e346dea576ae39c576a8f00d58edd1593</citedby><cites>FETCH-LOGICAL-c451t-c5007f5f7051ca11c6cbc516d4776f7e346dea576ae39c576a8f00d58edd1593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbi.2019.04.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30953766$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosenberg, Kenneth M.</creatorcontrib><creatorcontrib>Singh, Nevil J.</creatorcontrib><title>Mouse T cells express a neurotransmitter-receptor signature that is quantitatively modulated in a subset- and activation-dependent manner</title><title>Brain, behavior, and immunity</title><addtitle>Brain Behav Immun</addtitle><description>•Peripheral T cells transcribe less than 30 of the 185 annotated Neurotransmitter receptor genes.•More than half (14–16) of these NR transcripts are found in all subsets constituting a “core” signature.•We identify a narrow subset of <3 receptors that typify each T cell lineage or differentiation state.•The overall NR-signature of T cells seems refractory to tissue location and exhaustion.
Neurotransmitters are known to modulate the course of an immune response by targeting cells in both the innate and adaptive immune systems. Increasing evidence suggests that T cells, by expressing specific neurotransmitter receptors (NR) are directly regulated by them, leading to altered activation and skewed differentiation of the adaptive immune response. Given that gene expression in T cells changes in lineage- and activation-dependent fashion, it is expected that sensitivity to neurotransmitters may also vary along these lines. Here we generate an important resource for further analysis of this tier of immunoregulation, by identifying the distinct profile of NR transcripts that are expressed by peripheral T cells in mice, at different states of activation and differentiation. We find that only about 15% of the total annotated NR genes are transcribed in these T cells and most of them do not change in different subsets of T cells (CD8, CD4 – Naïve vs Memory vs Treg), or even when T cells migrate to different tissues. We suggest that the T cell-expressed NRs, found across all these subsets identifies a core, constitutive NR signature for the T cell lineage. In contrast, a very limited number (<2) of NRs were observed to mark each of the post-activation T cell states, suggesting that very specific neurotransmitter signals are available to modulate T cell responses in vivo in these subsets.</description><subject>Animals</subject><subject>Female</subject><subject>Lymphocyte Activation</subject><subject>Male</subject><subject>Mice, Inbred C57BL</subject><subject>Receptors, Neurotransmitter - genetics</subject><subject>Receptors, Neurotransmitter - metabolism</subject><subject>T-Lymphocyte Subsets - metabolism</subject><subject>T-Lymphocytes - metabolism</subject><issn>0889-1591</issn><issn>1090-2139</issn><issn>1090-2139</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhi1URJfCA3CpfOwl6TiJnUSVkFAFtFIRl71bjj1pvUrs1HZW9BH61ni1pYILpzn4m9-j_yPkE4OSAROXu3IYbFkB60toSoDqDdkw6KGoWN2fkA10XV8w3rNT8j7GHQDwmnXvyGkNPa9bITbk-YdfI9It1ThNkeKvJWCMVFGHa_ApKBdnmxKGIqDGJflAo713Kq0BaXpQidpIH1flkk0q2T1OT3T2Zp1UQkOty0lxHSKmgipnqNKZyZx3hcEFnUGX6Kycw_CBvB3VFPHjyzwj229ft9c3xd3P77fXX-4K3XCWCs0B2pGPLXCmFWNa6EFzJkzTtmJssW6EQcVbobDu9WF2I4DhHRqTq6jPyOdj7LIOMxqdDwhqkkuwswpP0isr_31x9kHe-70UQkDdtDng4iUg-McVY5KzjYf2lMPcpawqaETXA68yyo6oDj7GgOPrNwzkwaDcyWxQHgxKaGQ2mHfO_77vdeOPsgxcHQHMJe0tBhm1RafR2KwoSePtf-J_A7IDsNE</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Rosenberg, Kenneth M.</creator><creator>Singh, Nevil J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190801</creationdate><title>Mouse T cells express a neurotransmitter-receptor signature that is quantitatively modulated in a subset- and activation-dependent manner</title><author>Rosenberg, Kenneth M. ; Singh, Nevil J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-c5007f5f7051ca11c6cbc516d4776f7e346dea576ae39c576a8f00d58edd1593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Female</topic><topic>Lymphocyte Activation</topic><topic>Male</topic><topic>Mice, Inbred C57BL</topic><topic>Receptors, Neurotransmitter - genetics</topic><topic>Receptors, Neurotransmitter - metabolism</topic><topic>T-Lymphocyte Subsets - metabolism</topic><topic>T-Lymphocytes - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosenberg, Kenneth M.</creatorcontrib><creatorcontrib>Singh, Nevil J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brain, behavior, and immunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosenberg, Kenneth M.</au><au>Singh, Nevil J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mouse T cells express a neurotransmitter-receptor signature that is quantitatively modulated in a subset- and activation-dependent manner</atitle><jtitle>Brain, behavior, and immunity</jtitle><addtitle>Brain Behav Immun</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>80</volume><spage>275</spage><epage>285</epage><pages>275-285</pages><issn>0889-1591</issn><issn>1090-2139</issn><eissn>1090-2139</eissn><abstract>•Peripheral T cells transcribe less than 30 of the 185 annotated Neurotransmitter receptor genes.•More than half (14–16) of these NR transcripts are found in all subsets constituting a “core” signature.•We identify a narrow subset of <3 receptors that typify each T cell lineage or differentiation state.•The overall NR-signature of T cells seems refractory to tissue location and exhaustion.
Neurotransmitters are known to modulate the course of an immune response by targeting cells in both the innate and adaptive immune systems. Increasing evidence suggests that T cells, by expressing specific neurotransmitter receptors (NR) are directly regulated by them, leading to altered activation and skewed differentiation of the adaptive immune response. Given that gene expression in T cells changes in lineage- and activation-dependent fashion, it is expected that sensitivity to neurotransmitters may also vary along these lines. Here we generate an important resource for further analysis of this tier of immunoregulation, by identifying the distinct profile of NR transcripts that are expressed by peripheral T cells in mice, at different states of activation and differentiation. We find that only about 15% of the total annotated NR genes are transcribed in these T cells and most of them do not change in different subsets of T cells (CD8, CD4 – Naïve vs Memory vs Treg), or even when T cells migrate to different tissues. We suggest that the T cell-expressed NRs, found across all these subsets identifies a core, constitutive NR signature for the T cell lineage. In contrast, a very limited number (<2) of NRs were observed to mark each of the post-activation T cell states, suggesting that very specific neurotransmitter signals are available to modulate T cell responses in vivo in these subsets.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>30953766</pmid><doi>10.1016/j.bbi.2019.04.002</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Brain, behavior, and immunity, 2019-08, Vol.80, p.275-285 |
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| subjects | Animals Female Lymphocyte Activation Male Mice, Inbred C57BL Receptors, Neurotransmitter - genetics Receptors, Neurotransmitter - metabolism T-Lymphocyte Subsets - metabolism T-Lymphocytes - metabolism |
| title | Mouse T cells express a neurotransmitter-receptor signature that is quantitatively modulated in a subset- and activation-dependent manner |
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