MC4R and ENPP1 gene polymorphisms and their implication in maternal and neonatal risk for obesity

The aims of this study were to establish the role of MC4R rs17782313 and ENPP1 rs1044498 gene polymorphisms on pre-pregnancy BMI and the newborn’s status. We performed a cross-sectional study on 185 mothers and their offspring. The groups were divided into: control group- underweight or normal mothe...

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Veröffentlicht in:	Scientific reports 2019-07, Vol.9 (1), p.10858-9, Article 10858
Hauptverfasser:	Mărginean, Claudiu, Mărginean, Cristina Oana, Iancu, Mihaela, Meliț, Lorena Elena, Tripon, Florin, Bănescu, Claudia
Format:	Artikel
Sprache:	eng
Schlagworte:	38 45 45/44 59 692/308/3187 692/53/2423 96 96/47 Adult Arm Birth weight Birth Weight - genetics Body Mass Index Body Size Body weight Cross-Sectional Studies Female Genetic crosses Genotype Genotypes Gestational age Gestational Weight Gain - genetics Humanities and Social Sciences Humans Infant, Newborn multidisciplinary Neonates Obesity Obesity, Maternal - genetics Offspring Overweight Phosphoric Diester Hydrolases - genetics Polymorphism, Single Nucleotide Pregnancy Pyrophosphatases - genetics Receptor, Melanocortin, Type 4 - genetics Risk Factors Science Science (multidisciplinary) Skinfold Thickness Smoking Underweight Young Adult
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Zusammenfassung:	The aims of this study were to establish the role of MC4R rs17782313 and ENPP1 rs1044498 gene polymorphisms on pre-pregnancy BMI and the newborn’s status. We performed a cross-sectional study on 185 mothers and their offspring. The groups were divided into: control group- underweight or normal mothers with BMI initial
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-019-47402-2