De novo design of symmetric ferredoxins that shuttle electrons in vivo

A symmetric origin for bacterial ferredoxins was first proposed over 50 y ago, yet, to date, no functional symmetric molecule has been constructed. It is hypothesized that extant proteins have drifted from their symmetric roots via gene duplication followed by mutations. Phylogenetic analyses of ext...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-07, Vol.116 (29), p.14557-14562
Hauptverfasser:	Mutter, Andrew C., Tyryshkin, Alexei M., Campbell, Ian J., Poudel, Saroj, Bennett, George N., Silberg, Jonathan J., Nanda, Vikas, Falkowski, Paul G.
Format:	Artikel
Sprache:	eng
Schlagworte:	[4Fe-4S] clusters bacterial ferredoxin BASIC BIOLOGICAL SCIENCES Biological Sciences consensus design Consensus Sequence - genetics Design E coli Electron transfer Electron Transport - genetics Electrons Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Evolution, Molecular ferredoxin Ferredoxins - genetics Ferredoxins - metabolism Gene Duplication Life Sciences (General) Metabolic Engineering Metabolic Networks and Pathways - genetics Metabolic pathways metalloprotein microbiology Mutation Phylogeny protein evolution Space shuttles
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