Brønsted Acid-Mediated Domino One-Pot Dual C–C Bond Formation: Chemoselective Synthesis of Fused Tricyclic Ketones

A chemoselective synthesis of fused novel tricyclic motifs via a facile domino intramolecular cyclization is presented. The strategy enables the formation of dual C–C bond via intramolecular Friedel–Crafts alkylation followed by acylation to accomplish fused tricyclic ketones. Significantly, these fused tricyclic compounds are ubiquitous and constitute major structural cores of natural products.