Regulation of blood pressure is influenced by gender: A study in obese Zucker rats
The present study determined the role of renin-angiotensin system (RAS), endothelin system, and eicosanoid system in the blood pressure (BP) regulation in male and female Zucker rats, and whether the pressor response change similarly in lean and obese animals. In female (f) and male (m), lean (L) an...
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| Veröffentlicht in: | Life sciences (1973) 2018-09, Vol.209, p.236-241 |
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| description | The present study determined the role of renin-angiotensin system (RAS), endothelin system, and eicosanoid system in the blood pressure (BP) regulation in male and female Zucker rats, and whether the pressor response change similarly in lean and obese animals.
In female (f) and male (m), lean (L) and obese (O) Zucker rats (ZR) at 22 weeks old, we evaluated the role of the 3 mentioned systems using the following treatments: 1) enalapril (angiotensin I converting enzyme inhibitor), 2) the ABT-627 (endothelin receptor A (ETA) antagonist), and 3) the 1-aminobenzotriazol (1-ABT: eicosanoid synthesis inhibitor).
MAP by radiotelemetry was similar and significantly higher in mOZR (120 ± 2 mm Hg) and fOZR (116 ± 4 mm Hg) (p |
| doi_str_mv | 10.1016/j.lfs.2018.08.020 |
| format | Article |
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In female (f) and male (m), lean (L) and obese (O) Zucker rats (ZR) at 22 weeks old, we evaluated the role of the 3 mentioned systems using the following treatments: 1) enalapril (angiotensin I converting enzyme inhibitor), 2) the ABT-627 (endothelin receptor A (ETA) antagonist), and 3) the 1-aminobenzotriazol (1-ABT: eicosanoid synthesis inhibitor).
MAP by radiotelemetry was similar and significantly higher in mOZR (120 ± 2 mm Hg) and fOZR (116 ± 4 mm Hg) (p < 0.05 vs. m-, fLZR), than mLZR (105 ± 3 mm Hg) and fLZR (106 ± 1 mm Hg), that were also similar. Enalapril reduced MAP more in mOZR (23%) and mLZR (26%), than fLZR (20%, p < 0.905 vs. mLZR) or fOZR (9%; p < 0.05 vs. other groups). After 10 days of drug-free and recovery period, ABT-627 reduced MAP in fLZR and mLZR by similar amounts (102 ± 4 to 92 ± 3 mm Hg, n = 6; p < 0.05 and 105 ± 2 vs. 92 ± 3 mm Hg, n = 6; p < 0.05, respectively), but did not affect either fOZR or mOZR. After another 10 days of drug-free and recovery period, 1-ABT reduced MAP in fOZR (116 ± 4 to 95 ± 2, n = 6; p < 0.05), and did not affect all other groups.
We show that the mechanisms responsible for elevated BP in male and female OZR and LZR are different, and suggest that obesity may cause an increase in BP via different mechanisms in men and women as well.]]></description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2018.08.020</identifier><identifier>PMID: 30098343</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>20-HETE ; Angiotensin ; Angiotensin I ; Angiotensin-Converting Enzyme Inhibitors - therapeutic use ; Animals ; Blood pressure ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - prevention & control ; Endothelin ; Endothelins ; Enzyme inhibitors ; Female ; Hypertension ; Life sciences ; Male ; Obesity ; Obesity - physiopathology ; Rats ; Rats, Zucker ; Recovery ; Renin ; Renin-angiotensin system ; Renin-Angiotensin System - drug effects ; Rodents ; Sex Factors</subject><ispartof>Life sciences (1973), 2018-09, Vol.209, p.236-241</ispartof><rights>2018</rights><rights>Published by Elsevier Inc.</rights><rights>Copyright Elsevier BV Sep 15, 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-a149ec5059ba48f1cd839b0fce20ab2f538953ee37c49836226b2b0913fbdb353</citedby><cites>FETCH-LOGICAL-c479t-a149ec5059ba48f1cd839b0fce20ab2f538953ee37c49836226b2b0913fbdb353</cites><orcidid>0000-0002-3743-7420</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.lfs.2018.08.020$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30098343$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moulana, Mohadetheh</creatorcontrib><creatorcontrib>Maranon, Rodrigo O.</creatorcontrib><title>Regulation of blood pressure is influenced by gender: A study in obese Zucker rats</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description><![CDATA[The present study determined the role of renin-angiotensin system (RAS), endothelin system, and eicosanoid system in the blood pressure (BP) regulation in male and female Zucker rats, and whether the pressor response change similarly in lean and obese animals.
In female (f) and male (m), lean (L) and obese (O) Zucker rats (ZR) at 22 weeks old, we evaluated the role of the 3 mentioned systems using the following treatments: 1) enalapril (angiotensin I converting enzyme inhibitor), 2) the ABT-627 (endothelin receptor A (ETA) antagonist), and 3) the 1-aminobenzotriazol (1-ABT: eicosanoid synthesis inhibitor).
MAP by radiotelemetry was similar and significantly higher in mOZR (120 ± 2 mm Hg) and fOZR (116 ± 4 mm Hg) (p < 0.05 vs. m-, fLZR), than mLZR (105 ± 3 mm Hg) and fLZR (106 ± 1 mm Hg), that were also similar. Enalapril reduced MAP more in mOZR (23%) and mLZR (26%), than fLZR (20%, p < 0.905 vs. mLZR) or fOZR (9%; p < 0.05 vs. other groups). After 10 days of drug-free and recovery period, ABT-627 reduced MAP in fLZR and mLZR by similar amounts (102 ± 4 to 92 ± 3 mm Hg, n = 6; p < 0.05 and 105 ± 2 vs. 92 ± 3 mm Hg, n = 6; p < 0.05, respectively), but did not affect either fOZR or mOZR. After another 10 days of drug-free and recovery period, 1-ABT reduced MAP in fOZR (116 ± 4 to 95 ± 2, n = 6; p < 0.05), and did not affect all other groups.
We show that the mechanisms responsible for elevated BP in male and female OZR and LZR are different, and suggest that obesity may cause an increase in BP via different mechanisms in men and women as well.]]></description><subject>20-HETE</subject><subject>Angiotensin</subject><subject>Angiotensin I</subject><subject>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</subject><subject>Animals</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - physiology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular Diseases - prevention & control</subject><subject>Endothelin</subject><subject>Endothelins</subject><subject>Enzyme inhibitors</subject><subject>Female</subject><subject>Hypertension</subject><subject>Life sciences</subject><subject>Male</subject><subject>Obesity</subject><subject>Obesity - physiopathology</subject><subject>Rats</subject><subject>Rats, Zucker</subject><subject>Recovery</subject><subject>Renin</subject><subject>Renin-angiotensin system</subject><subject>Renin-Angiotensin System - drug effects</subject><subject>Rodents</subject><subject>Sex Factors</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo7rj6A7xIwIuXHitJpztREJbFL1gQFr14CUm6eszY0xmTzsL8ezPOuqgHoaAO9dRbHy8hTxmsGbDu5XY9jXnNgak11OBwj6yY6nUDnWD3yQqAt43gIM_Io5y3ACBlLx6SMwGglWjFilxf46ZMdglxpnGkbopxoPuEOZeENGQa5nEqOHscqDvQDc4Dplf0gualDIdapdFhRvq1-O-YaLJLfkwejHbK-OQ2n5Mv795-vvzQXH16__Hy4qrxba-XxrJWo5cgtbOtGpkflNAORo8crOOjFEpLgSh639ZlO847xx1oJkY3OCHFOXlz0t0Xt8PB47wkO5l9CjubDibaYP6uzOGb2cQb03VCA9NV4MWtQIo_CubF7EL2OE12xliy4aB6WefBEX3-D7qNJc31PMMZU0J1UohKsRPlU8w54Xi3DANzdMxsTXXMHB0zUIND7Xn25xV3Hb8tqsDrE4D1lzcBk8k-_DIkJPSLGWL4j_xPr52mpQ</recordid><startdate>20180915</startdate><enddate>20180915</enddate><creator>Moulana, Mohadetheh</creator><creator>Maranon, Rodrigo O.</creator><general>Elsevier Inc</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3743-7420</orcidid></search><sort><creationdate>20180915</creationdate><title>Regulation of blood pressure is influenced by gender: A study in obese Zucker rats</title><author>Moulana, Mohadetheh ; Maranon, Rodrigo O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-a149ec5059ba48f1cd839b0fce20ab2f538953ee37c49836226b2b0913fbdb353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>20-HETE</topic><topic>Angiotensin</topic><topic>Angiotensin I</topic><topic>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</topic><topic>Animals</topic><topic>Blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Pressure - physiology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cardiovascular Diseases - prevention & control</topic><topic>Endothelin</topic><topic>Endothelins</topic><topic>Enzyme inhibitors</topic><topic>Female</topic><topic>Hypertension</topic><topic>Life sciences</topic><topic>Male</topic><topic>Obesity</topic><topic>Obesity - physiopathology</topic><topic>Rats</topic><topic>Rats, Zucker</topic><topic>Recovery</topic><topic>Renin</topic><topic>Renin-angiotensin system</topic><topic>Renin-Angiotensin System - drug effects</topic><topic>Rodents</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moulana, Mohadetheh</creatorcontrib><creatorcontrib>Maranon, Rodrigo O.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moulana, Mohadetheh</au><au>Maranon, Rodrigo O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of blood pressure is influenced by gender: A study in obese Zucker rats</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2018-09-15</date><risdate>2018</risdate><volume>209</volume><spage>236</spage><epage>241</epage><pages>236-241</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract><![CDATA[The present study determined the role of renin-angiotensin system (RAS), endothelin system, and eicosanoid system in the blood pressure (BP) regulation in male and female Zucker rats, and whether the pressor response change similarly in lean and obese animals.
In female (f) and male (m), lean (L) and obese (O) Zucker rats (ZR) at 22 weeks old, we evaluated the role of the 3 mentioned systems using the following treatments: 1) enalapril (angiotensin I converting enzyme inhibitor), 2) the ABT-627 (endothelin receptor A (ETA) antagonist), and 3) the 1-aminobenzotriazol (1-ABT: eicosanoid synthesis inhibitor).
MAP by radiotelemetry was similar and significantly higher in mOZR (120 ± 2 mm Hg) and fOZR (116 ± 4 mm Hg) (p < 0.05 vs. m-, fLZR), than mLZR (105 ± 3 mm Hg) and fLZR (106 ± 1 mm Hg), that were also similar. Enalapril reduced MAP more in mOZR (23%) and mLZR (26%), than fLZR (20%, p < 0.905 vs. mLZR) or fOZR (9%; p < 0.05 vs. other groups). After 10 days of drug-free and recovery period, ABT-627 reduced MAP in fLZR and mLZR by similar amounts (102 ± 4 to 92 ± 3 mm Hg, n = 6; p < 0.05 and 105 ± 2 vs. 92 ± 3 mm Hg, n = 6; p < 0.05, respectively), but did not affect either fOZR or mOZR. After another 10 days of drug-free and recovery period, 1-ABT reduced MAP in fOZR (116 ± 4 to 95 ± 2, n = 6; p < 0.05), and did not affect all other groups.
We show that the mechanisms responsible for elevated BP in male and female OZR and LZR are different, and suggest that obesity may cause an increase in BP via different mechanisms in men and women as well.]]></abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>30098343</pmid><doi>10.1016/j.lfs.2018.08.020</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-3743-7420</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 20-HETE Angiotensin Angiotensin I Angiotensin-Converting Enzyme Inhibitors - therapeutic use Animals Blood pressure Blood Pressure - drug effects Blood Pressure - physiology Cardiovascular Diseases - etiology Cardiovascular Diseases - prevention & control Endothelin Endothelins Enzyme inhibitors Female Hypertension Life sciences Male Obesity Obesity - physiopathology Rats Rats, Zucker Recovery Renin Renin-angiotensin system Renin-Angiotensin System - drug effects Rodents Sex Factors |
| title | Regulation of blood pressure is influenced by gender: A study in obese Zucker rats |
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