Regulation of blood pressure is influenced by gender: A study in obese Zucker rats

The present study determined the role of renin-angiotensin system (RAS), endothelin system, and eicosanoid system in the blood pressure (BP) regulation in male and female Zucker rats, and whether the pressor response change similarly in lean and obese animals. In female (f) and male (m), lean (L) an...

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Veröffentlicht in:	Life sciences (1973) 2018-09, Vol.209, p.236-241
Hauptverfasser:	Moulana, Mohadetheh, Maranon, Rodrigo O.
Format:	Artikel
Sprache:	eng
Schlagworte:	20-HETE Angiotensin Angiotensin I Angiotensin-Converting Enzyme Inhibitors - therapeutic use Animals Blood pressure Blood Pressure - drug effects Blood Pressure - physiology Cardiovascular Diseases - etiology Cardiovascular Diseases - prevention & control Endothelin Endothelins Enzyme inhibitors Female Hypertension Life sciences Male Obesity Obesity - physiopathology Rats Rats, Zucker Recovery Renin Renin-angiotensin system Renin-Angiotensin System - drug effects Rodents Sex Factors
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Zusammenfassung:	The present study determined the role of renin-angiotensin system (RAS), endothelin system, and eicosanoid system in the blood pressure (BP) regulation in male and female Zucker rats, and whether the pressor response change similarly in lean and obese animals. In female (f) and male (m), lean (L) and obese (O) Zucker rats (ZR) at 22 weeks old, we evaluated the role of the 3 mentioned systems using the following treatments: 1) enalapril (angiotensin I converting enzyme inhibitor), 2) the ABT-627 (endothelin receptor A (ETA) antagonist), and 3) the 1-aminobenzotriazol (1-ABT: eicosanoid synthesis inhibitor). MAP by radiotelemetry was similar and significantly higher in mOZR (120 ± 2 mm Hg) and fOZR (116 ± 4 mm Hg) (p
ISSN:	0024-3205 1879-0631
DOI:	10.1016/j.lfs.2018.08.020