Neuropsychiatric Disturbances and Diabetes Mellitus: The Role of Oxidative Stress

More specifically, G. Z. Réus et al. highlight that depression and T2D share OS, inflammation, and metabolic disturbances as common pathophysiological mechanisms, while B. Carpita et al. discuss maternal diabetes (and the related oxidative and inflammatory condition) as a risk factor for the development of autism spectrum disorders in the offspring. C. Chen et al. demonstrate that irbesartan pretreatment protects pancreatic β-cells from apoptosis while improving glucose levels and insulin secretion in streptozotocin-induced acute prediabetic mice. M. Maciejczyk et al., evaluating redox homeostasis and oxidative damage in the cerebral cortex and hypothalamus of rats under insulin resistance conditions, describe an adaptive (although ineffective in terms of neuroprotection) increase in the antioxidant defense systems.