Denosumab Versus Risedronate in Glucocorticoid‐Induced Osteoporosis: Final Results of a Twenty‐Four–Month Randomized, Double‐Blind, Double‐Dummy Trial

Objective Clinical trial results have shown that, in glucocorticoid‐treated patients, treatment with denosumab 60 mg subcutaneously once every 6 months (Q6M) increased spine and hip bone mineral density (BMD) at month 12 significantly more than treatment with risedronate 5 mg orally once daily (QD)....

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Veröffentlicht in:Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2019-07, Vol.71 (7), p.1174-1184
Hauptverfasser: Saag, Kenneth G., Pannacciulli, Nicola, Geusens, Piet, Adachi, Jonathan D., Messina, Osvaldo D., Morales‐Torres, Jorge, Emkey, Ronald, Butler, Peter W., Yin, Xiang, Lems, Willem F.
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Sprache:eng
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Zusammenfassung:Objective Clinical trial results have shown that, in glucocorticoid‐treated patients, treatment with denosumab 60 mg subcutaneously once every 6 months (Q6M) increased spine and hip bone mineral density (BMD) at month 12 significantly more than treatment with risedronate 5 mg orally once daily (QD). The present analysis was performed to compare efficacy and characterize safety through month 24. Methods This phase III study enrolled men and women ≥18 years old who had received ≥7.5 mg daily prednisone or equivalent for
ISSN:2326-5191
2326-5205
DOI:10.1002/art.40874