Association of OSAHS Hypoxia Indicators with Early Renal Injury and Serum Fibroblast Growth Factor 21 in Obese Type 2 Diabetic Patients

Association of OSAHS Hypoxia Indicators with Early Renal Injury and Serum Fibroblast Growth Factor 21 in Obese Type 2 Diabetic Patients

Objective This study aimed to explore the association of obstructive sleep apnea-hypopnea syndrome (OSAHS) hypoxia indicators with early renal injury and serum fibroblast growth factor 21 (FGF21) in obese type 2 diabetic patients. Methods A total of 109 obese patients with type 2 diabetes mellitus (...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Diabetes therapy 2019-08, Vol.10 (4), p.1357-1368
Hauptverfasser: Yu, Weinan, Wang, Xiaoqing, Ni, Yaojun, Huai, De, Hao, Hairong, Li, Qingjun, Liu, Ziyu, Wen, Surong, Cheng, Liang, Hu, Wen
Format: Artikel
Sprache:eng
Schlagworte:
Cardiology
Care and treatment
ChiCTR
ChiCTR-IOR-15006225
Complications and side effects
Correlation analysis
Diabetes
Diabetic nephropathy
Diagnosis
Drug therapy
Endocrinology
Fibroblasts
Growth factors
Hypoxia
Internal Medicine
Kidney diseases
Medicine
Medicine & Public Health
Obesity
Original Research
Oxygen saturation
Prevention
Risk factors
Sleep apnea
Sleep apnea syndromes
Type 2 diabetes
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Objective This study aimed to explore the association of obstructive sleep apnea-hypopnea syndrome (OSAHS) hypoxia indicators with early renal injury and serum fibroblast growth factor 21 (FGF21) in obese type 2 diabetic patients. Methods A total of 109 obese patients with type 2 diabetes mellitus (T2DM) were recruited, including 70 males and 39 females, with an average age of 52.77 ± 13.57 years and average BMI of 29.08 ± 4.36 kg/m 2 . Overnight sleep monitoring was performed with a portable monitor to record respiratory parameters [apnea-hypopnea index (AHI), oxygen desaturation index (ODI), lowest oxygen saturation (LSaO 2 ), mean oxygen saturation (MSaO 2 /MPO 2 ) and cumulative time of oxygen saturation < 90% (CT 
ISSN:1869-6953
1869-6961
DOI:10.1007/s13300-019-0639-x