Evaluating growth failure with diffusion tensor imaging in pediatric survivors of high-risk neuroblastoma treated with high-dose cis-retinoic acid

Background The survival of patients with high-risk neuroblastoma has increased with multimodal therapy, but most survivors demonstrate growth failure. Objective To assess physeal abnormalities in children with high-risk neuroblastoma in comparison to normal controls by using diffusion tensor imaging...

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Veröffentlicht in:Pediatric radiology 2019-07, Vol.49 (8), p.1056-1065
Hauptverfasser: Delgado, Jorge, Jaramillo, Diego, Chauvin, Nancy A., Guo, Michelle, Stratton, Mackenzie S., Sweeney, Hannah E., Barrera, Christian A., Mostoufi-Moab, Sogol
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Sprache:eng
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Zusammenfassung:Background The survival of patients with high-risk neuroblastoma has increased with multimodal therapy, but most survivors demonstrate growth failure. Objective To assess physeal abnormalities in children with high-risk neuroblastoma in comparison to normal controls by using diffusion tensor imaging (DTI) of the distal femoral physis and adjacent metaphysis. Materials and methods We prospectively obtained physeal DTI at 3.0 T in 20 subjects (mean age: 12.4 years, 7 females) with high-risk neuroblastoma treated with high-dose cis-retinoic acid, and 20 age- and gender-matched controls. We compared fractional anisotropy (FA), normalized tract volume (cm 3 /cm 2 ) and tract concentration (tracts/cm 2 ) between the groups, in relation to height Z-score and response to growth hormone therapy. Tractography images were evaluated qualitatively. Results DTI parameters were significantly lower in high-risk neuroblastoma survivors compared to controls ( P
ISSN:0301-0449
1432-1998
DOI:10.1007/s00247-019-04409-1