Nitroglycerin-Citrate-Ethanol Catheter Lock Solution Is Highly Effective for In Vitro Eradication of Candida auris Biofilm

poses emerging risks for causing severe central line-associated bloodstream infections. We tested the ability of antifungal lock solutions to rapidly eradicate biofilms. Liposomal amphotericin B, amphotericin B deoxycholate, fluconazole, voriconazole, micafungin, caspofungin, and anidulafungin faile...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2019-07, Vol.63 (7)
Hauptverfasser:	Vargas-Cruz, Nylev, Reitzel, Ruth A, Rosenblatt, Joel, Chaftari, Anne-Marie, Wilson Dib, Rita, Hachem, Ray, Kontoyiannis, Dimitrios P, Raad, Issam I
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphotericin B - pharmacology Anidulafungin - pharmacology Antifungal Agents Antifungal Agents - pharmacology Biofilms Candida Candida - drug effects Caspofungin - pharmacology Catheter-Related Infections - prevention & control Catheters Catheters - microbiology Citric Acid Citric Acid - pharmacology Ethanol - pharmacology Experimental Therapeutics Fluconazole - pharmacology Micafungin - pharmacology Nitroglycerin Nitroglycerin - pharmacology Pharmaceutical Solutions Voriconazole - pharmacology
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Zusammenfassung:	poses emerging risks for causing severe central line-associated bloodstream infections. We tested the ability of antifungal lock solutions to rapidly eradicate biofilms. Liposomal amphotericin B, amphotericin B deoxycholate, fluconazole, voriconazole, micafungin, caspofungin, and anidulafungin failed to completely eradicate all 10 tested biofilms. Conversely, nitroglycerin-citrate-ethanol (NiCE) catheter lock solution completely eradicated all replicates for all of biofilms tested.
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.00299-19