Transcriptome Analysis of Long-lived Drosophila melanogaster E(z) Mutants Sheds Light on the Molecular Mechanisms of Longevity
The E ( z ) histone methyltransferase heterozygous mutation in Drosophila is known to increase lifespan and stress resistance. However, the longevity mechanisms of E ( z ) mutants have not been revealed. Using genome-wide transcriptome analysis, we demonstrated that lifespan extension, increase of r...
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| Veröffentlicht in: | Scientific reports 2019-06, Vol.9 (1), p.9151-11, Article 9151 |
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| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | The
E
(
z
) histone methyltransferase heterozygous mutation in
Drosophila
is known to increase lifespan and stress resistance. However, the longevity mechanisms of
E
(
z
) mutants have not been revealed. Using genome-wide transcriptome analysis, we demonstrated that lifespan extension, increase of resistance to hyperthermia, oxidative stress and endoplasmic reticulum stress, and fecundity enhancement in
E
(
z
) heterozygous mutants are accompanied by changes in the expression level of 239 genes (p |
|---|---|
| ISSN: | 2045-2322 2045-2322 |
| DOI: | 10.1038/s41598-019-45714-x |