The Expanding and Unexpected Functions of Mitochondria Contact Sites

Mitochondria make functionally relevant contacts with most, if not all, other organelles in the cell. These contacts impact on mitochondrial behavior and function as well as on a wide variety of cellular functions. Many recent advances have been made in the rapidly growing field of mitochondria cont...

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Veröffentlicht in:Trends in cell biology 2019-07, Vol.29 (7), p.580-590
1. Verfasser: Lackner, Laura L.
Format: Artikel
Sprache:eng
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Zusammenfassung:Mitochondria make functionally relevant contacts with most, if not all, other organelles in the cell. These contacts impact on mitochondrial behavior and function as well as on a wide variety of cellular functions. Many recent advances have been made in the rapidly growing field of mitochondria contact site biology, and these advances have expanded the known functions of mitochondria contact sites in exciting and unexpected ways. Mitochondria make functionally relevant contacts with most, if not all, other organelles in the cell.Mitochondria–organelle contacts impact on many aspects of mitochondrial behavior and function.The functions of mitochondria–organelle contact extend beyond the mitochondrion itself and impact on an interorganelle communication network and, consequently, on a wide variety of cellular functions.Many mitochondrial contact site proteins localize to multiple contact sites.Many mitochondrial contact site proteins function in other crucial cellular processes, such as protein import, vesicular trafficking, and membrane remodeling pathways. It is unclear how these canonical functions are integrated with contact site function.Mitochondria–organelle contacts are part of a complex and dynamic organelle interaction network that integrates organelle communication and function with cellular metabolism and homeostasis.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2019.02.009