Sequential Functionalization of meta-C–H and ipso-C–O Bonds of Phenols

The use of a template as a linchpin motif in directed remote C–H functionalization is a versatile yet relatively underexplored strategy. We have developed a template-directed approach to realizing one-pot sequential palladium-catalyzed meta-selective C–H olefination of phenols, and nickel-catalyzed...

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Veröffentlicht in:	Journal of the American Chemical Society 2019-02, Vol.141 (5), p.1903-1907
Hauptverfasser:	Xu, Jiancong, Chen, Jingjing, Gao, Feng, Xie, Shuguang, Xu, Xiaohua, Jin, Zhong, Yu, Jin-Quan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes - chemical synthesis Alkenes - chemistry aromatic hydrocarbons arylation carbon-hydrogen bond activation Catalysis catalytic activity chemical bonding Molecular Structure Nickel - chemistry palladium phenols Phenols - chemistry
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Beschreibung
Zusammenfassung:	The use of a template as a linchpin motif in directed remote C–H functionalization is a versatile yet relatively underexplored strategy. We have developed a template-directed approach to realizing one-pot sequential palladium-catalyzed meta-selective C–H olefination of phenols, and nickel-catalyzed ipso-C–O activation and arylation. Thus, this bifunctional template converts phenols to synthetically useful 1,3-disubstituted arenes.
ISSN:	0002-7863 1520-5126 1520-5126
DOI:	10.1021/jacs.8b13403