Coronary circulating mononuclear progenitor cells and soluble biomarkers in the cardiovascular prognosis after coronary angioplasty
Currently, there are no confident prognostic markers in patients with coronary artery disease (CAD) undergoing angioplasty. The present study aimed to explore whether basal coronary circulating Mononuclear Progenitor Cells (MPCs) and vascular injury biomarkers were related to development of major ad...
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| Veröffentlicht in: | Journal of cellular and molecular medicine 2019-07, Vol.23 (7), p.4844-4849 |
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| creator | Suárez‐Cuenca, Juan Antonio Robledo‐Nolasco, Rogelio Alcántara‐Meléndez, Marco Antonio Díaz Hernández, Luis Javier Vera‐Gómez, Eduardo Hernández‐Patricio, Alejandro Sánchez‐Díaz, Karla Susana Buendía‐Gutiérrez, Juan Ariel Contreras‐Ramos, Alejandra Ruíz‐Hernández, Atzin Suá Pérez‐Cabeza de Vaca, Rebeca Mondragón‐Terán, Paul |
| description | Currently, there are no confident prognostic markers in patients with coronary artery disease (CAD) undergoing angioplasty. The present study aimed to explore whether basal coronary circulating Mononuclear Progenitor Cells (MPCs) and vascular injury biomarkers were related to development of major adverse cardiovascular events (MACEs) and may impact clinical prognosis.
Methods
The number of MPCs and soluble mediators such as IL‐1β, sICAM‐1, MMP‐9, malondialdehyde, superoxide dismutase and nitric oxide were determined in coronary and peripheral circulation. Prognostic ability for MACEs occurring at 6 months follow up was assessed by time‐to‐event and event free survival estimations.
Results
Lower coronary circulating MPCs subpopulations CD45+CD34+, CD45+CD34+CD133+CD184+, lower MMP‐9 and higher sICAM‐1 significantly associated with MACEs presentation and showed prognostic ability; while peripheral blood increase in malondialdehyde and decreased superoxide dismutase were observed in patients with MACEs.
Conclusion
Coronary concentration of biomarkers related with vascular repair, such as MPCs subpopulations and adhesion molecules, may predict MACEs and impact prognosis in patients with CAD undergoing angioplasty; whereas peripheral pro‐oxidative condition may be also associated. |
| doi_str_mv | 10.1111/jcmm.14336 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6584722</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2247641503</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4486-4fb25a9e75abe24c9892128e1a12bf79ba980b288d461de08778ae488392674c3</originalsourceid><addsrcrecordid>eNp9kU1P3DAQhq2qVaG0l_4AZKm3SgvxRxz7goRW_QCBuLRny3Emi7eOvdgJ1Z754_WSBcGlvtjSPPPMWC9Cn0l1Qso5XdthOCGcMfEGHZJa0gVXjL_dv4lk8gB9yHldVUwQpt6jA0YqoVQtDtHDMqYYTNpi65KdvBldWOEhhhgm68EkvElxBcGNMWEL3mdsQodz9FPrAbcuDib9gZSxC3i8BWxN6ly8N3knm7tDzK609SMUxdM4E1YubrzJ4_Yjetcbn-HT_j5Cv79_-7X8ubi6-XGxPL9aWM6lWPC-pbVR0NSmBcqtkooSKoEYQtu-Ua1RsmqplB0XpINKNo00wKVkioqGW3aEzmbvZmoH6CyEMRmvN8mVP2x1NE6_rgR3q1fxXota8obSIviyF6R4N0Ee9TpOKZSdNaW8EZzUFSvU15myKeacoH-eQCq9C0zvAtOPgRX4-OVOz-hTQgUgM_DXedj-R6Uvl9fXs_QfnUalbg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2247641503</pqid></control><display><type>article</type><title>Coronary circulating mononuclear progenitor cells and soluble biomarkers in the cardiovascular prognosis after coronary angioplasty</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Online Library Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Suárez‐Cuenca, Juan Antonio ; Robledo‐Nolasco, Rogelio ; Alcántara‐Meléndez, Marco Antonio ; Díaz Hernández, Luis Javier ; Vera‐Gómez, Eduardo ; Hernández‐Patricio, Alejandro ; Sánchez‐Díaz, Karla Susana ; Buendía‐Gutiérrez, Juan Ariel ; Contreras‐Ramos, Alejandra ; Ruíz‐Hernández, Atzin Suá ; Pérez‐Cabeza de Vaca, Rebeca ; Mondragón‐Terán, Paul</creator><creatorcontrib>Suárez‐Cuenca, Juan Antonio ; Robledo‐Nolasco, Rogelio ; Alcántara‐Meléndez, Marco Antonio ; Díaz Hernández, Luis Javier ; Vera‐Gómez, Eduardo ; Hernández‐Patricio, Alejandro ; Sánchez‐Díaz, Karla Susana ; Buendía‐Gutiérrez, Juan Ariel ; Contreras‐Ramos, Alejandra ; Ruíz‐Hernández, Atzin Suá ; Pérez‐Cabeza de Vaca, Rebeca ; Mondragón‐Terán, Paul</creatorcontrib><description>Currently, there are no confident prognostic markers in patients with coronary artery disease (CAD) undergoing angioplasty. The present study aimed to explore whether basal coronary circulating Mononuclear Progenitor Cells (MPCs) and vascular injury biomarkers were related to development of major adverse cardiovascular events (MACEs) and may impact clinical prognosis.
Methods
The number of MPCs and soluble mediators such as IL‐1β, sICAM‐1, MMP‐9, malondialdehyde, superoxide dismutase and nitric oxide were determined in coronary and peripheral circulation. Prognostic ability for MACEs occurring at 6 months follow up was assessed by time‐to‐event and event free survival estimations.
Results
Lower coronary circulating MPCs subpopulations CD45+CD34+, CD45+CD34+CD133+CD184+, lower MMP‐9 and higher sICAM‐1 significantly associated with MACEs presentation and showed prognostic ability; while peripheral blood increase in malondialdehyde and decreased superoxide dismutase were observed in patients with MACEs.
Conclusion
Coronary concentration of biomarkers related with vascular repair, such as MPCs subpopulations and adhesion molecules, may predict MACEs and impact prognosis in patients with CAD undergoing angioplasty; whereas peripheral pro‐oxidative condition may be also associated.</description><identifier>ISSN: 1582-1838</identifier><identifier>EISSN: 1582-4934</identifier><identifier>DOI: 10.1111/jcmm.14336</identifier><identifier>PMID: 31069956</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Aged ; Angina pectoris ; Angioplasty ; Biomarkers ; Biomarkers - blood ; Blood pressure ; Cardiovascular disease ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - diagnosis ; CD18 antigen ; CD34 antigen ; CD45 antigen ; Coronary artery ; Coronary artery disease ; Coronary Circulation ; Diabetes ; EPCs ; Female ; Flow cytometry ; Heart attacks ; Heart diseases ; Heart failure ; Humans ; Hypertension ; Leukocytes, Mononuclear - pathology ; MACEs ; Male ; Malondialdehyde ; Medical imaging ; Medical prognosis ; MMP‐9 ; Nitric oxide ; Peripheral blood ; Peripheral circulation ; Population ; Progenitor cells ; Prognosis ; Short Communication ; Short Communications ; sICAM‐1 ; SOD ; Solubility ; Statistical analysis ; Stem cells ; Stem Cells - pathology ; Studies ; Subpopulations ; Superoxide dismutase ; Survival analysis</subject><ispartof>Journal of cellular and molecular medicine, 2019-07, Vol.23 (7), p.4844-4849</ispartof><rights>2019 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.</rights><rights>2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4486-4fb25a9e75abe24c9892128e1a12bf79ba980b288d461de08778ae488392674c3</citedby><cites>FETCH-LOGICAL-c4486-4fb25a9e75abe24c9892128e1a12bf79ba980b288d461de08778ae488392674c3</cites><orcidid>0000-0002-2098-5658</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584722/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584722/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11542,27903,27904,45553,45554,46030,46454,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31069956$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suárez‐Cuenca, Juan Antonio</creatorcontrib><creatorcontrib>Robledo‐Nolasco, Rogelio</creatorcontrib><creatorcontrib>Alcántara‐Meléndez, Marco Antonio</creatorcontrib><creatorcontrib>Díaz Hernández, Luis Javier</creatorcontrib><creatorcontrib>Vera‐Gómez, Eduardo</creatorcontrib><creatorcontrib>Hernández‐Patricio, Alejandro</creatorcontrib><creatorcontrib>Sánchez‐Díaz, Karla Susana</creatorcontrib><creatorcontrib>Buendía‐Gutiérrez, Juan Ariel</creatorcontrib><creatorcontrib>Contreras‐Ramos, Alejandra</creatorcontrib><creatorcontrib>Ruíz‐Hernández, Atzin Suá</creatorcontrib><creatorcontrib>Pérez‐Cabeza de Vaca, Rebeca</creatorcontrib><creatorcontrib>Mondragón‐Terán, Paul</creatorcontrib><title>Coronary circulating mononuclear progenitor cells and soluble biomarkers in the cardiovascular prognosis after coronary angioplasty</title><title>Journal of cellular and molecular medicine</title><addtitle>J Cell Mol Med</addtitle><description>Currently, there are no confident prognostic markers in patients with coronary artery disease (CAD) undergoing angioplasty. The present study aimed to explore whether basal coronary circulating Mononuclear Progenitor Cells (MPCs) and vascular injury biomarkers were related to development of major adverse cardiovascular events (MACEs) and may impact clinical prognosis.
Methods
The number of MPCs and soluble mediators such as IL‐1β, sICAM‐1, MMP‐9, malondialdehyde, superoxide dismutase and nitric oxide were determined in coronary and peripheral circulation. Prognostic ability for MACEs occurring at 6 months follow up was assessed by time‐to‐event and event free survival estimations.
Results
Lower coronary circulating MPCs subpopulations CD45+CD34+, CD45+CD34+CD133+CD184+, lower MMP‐9 and higher sICAM‐1 significantly associated with MACEs presentation and showed prognostic ability; while peripheral blood increase in malondialdehyde and decreased superoxide dismutase were observed in patients with MACEs.
Conclusion
Coronary concentration of biomarkers related with vascular repair, such as MPCs subpopulations and adhesion molecules, may predict MACEs and impact prognosis in patients with CAD undergoing angioplasty; whereas peripheral pro‐oxidative condition may be also associated.</description><subject>Aged</subject><subject>Angina pectoris</subject><subject>Angioplasty</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Blood pressure</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>CD18 antigen</subject><subject>CD34 antigen</subject><subject>CD45 antigen</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Coronary Circulation</subject><subject>Diabetes</subject><subject>EPCs</subject><subject>Female</subject><subject>Flow cytometry</subject><subject>Heart attacks</subject><subject>Heart diseases</subject><subject>Heart failure</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Leukocytes, Mononuclear - pathology</subject><subject>MACEs</subject><subject>Male</subject><subject>Malondialdehyde</subject><subject>Medical imaging</subject><subject>Medical prognosis</subject><subject>MMP‐9</subject><subject>Nitric oxide</subject><subject>Peripheral blood</subject><subject>Peripheral circulation</subject><subject>Population</subject><subject>Progenitor cells</subject><subject>Prognosis</subject><subject>Short Communication</subject><subject>Short Communications</subject><subject>sICAM‐1</subject><subject>SOD</subject><subject>Solubility</subject><subject>Statistical analysis</subject><subject>Stem cells</subject><subject>Stem Cells - pathology</subject><subject>Studies</subject><subject>Subpopulations</subject><subject>Superoxide dismutase</subject><subject>Survival analysis</subject><issn>1582-1838</issn><issn>1582-4934</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1P3DAQhq2qVaG0l_4AZKm3SgvxRxz7goRW_QCBuLRny3Emi7eOvdgJ1Z754_WSBcGlvtjSPPPMWC9Cn0l1Qso5XdthOCGcMfEGHZJa0gVXjL_dv4lk8gB9yHldVUwQpt6jA0YqoVQtDtHDMqYYTNpi65KdvBldWOEhhhgm68EkvElxBcGNMWEL3mdsQodz9FPrAbcuDib9gZSxC3i8BWxN6ly8N3knm7tDzK609SMUxdM4E1YubrzJ4_Yjetcbn-HT_j5Cv79_-7X8ubi6-XGxPL9aWM6lWPC-pbVR0NSmBcqtkooSKoEYQtu-Ua1RsmqplB0XpINKNo00wKVkioqGW3aEzmbvZmoH6CyEMRmvN8mVP2x1NE6_rgR3q1fxXota8obSIviyF6R4N0Ee9TpOKZSdNaW8EZzUFSvU15myKeacoH-eQCq9C0zvAtOPgRX4-OVOz-hTQgUgM_DXedj-R6Uvl9fXs_QfnUalbg</recordid><startdate>201907</startdate><enddate>201907</enddate><creator>Suárez‐Cuenca, Juan Antonio</creator><creator>Robledo‐Nolasco, Rogelio</creator><creator>Alcántara‐Meléndez, Marco Antonio</creator><creator>Díaz Hernández, Luis Javier</creator><creator>Vera‐Gómez, Eduardo</creator><creator>Hernández‐Patricio, Alejandro</creator><creator>Sánchez‐Díaz, Karla Susana</creator><creator>Buendía‐Gutiérrez, Juan Ariel</creator><creator>Contreras‐Ramos, Alejandra</creator><creator>Ruíz‐Hernández, Atzin Suá</creator><creator>Pérez‐Cabeza de Vaca, Rebeca</creator><creator>Mondragón‐Terán, Paul</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2098-5658</orcidid></search><sort><creationdate>201907</creationdate><title>Coronary circulating mononuclear progenitor cells and soluble biomarkers in the cardiovascular prognosis after coronary angioplasty</title><author>Suárez‐Cuenca, Juan Antonio ; Robledo‐Nolasco, Rogelio ; Alcántara‐Meléndez, Marco Antonio ; Díaz Hernández, Luis Javier ; Vera‐Gómez, Eduardo ; Hernández‐Patricio, Alejandro ; Sánchez‐Díaz, Karla Susana ; Buendía‐Gutiérrez, Juan Ariel ; Contreras‐Ramos, Alejandra ; Ruíz‐Hernández, Atzin Suá ; Pérez‐Cabeza de Vaca, Rebeca ; Mondragón‐Terán, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4486-4fb25a9e75abe24c9892128e1a12bf79ba980b288d461de08778ae488392674c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>Angina pectoris</topic><topic>Angioplasty</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Blood pressure</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>CD18 antigen</topic><topic>CD34 antigen</topic><topic>CD45 antigen</topic><topic>Coronary artery</topic><topic>Coronary artery disease</topic><topic>Coronary Circulation</topic><topic>Diabetes</topic><topic>EPCs</topic><topic>Female</topic><topic>Flow cytometry</topic><topic>Heart attacks</topic><topic>Heart diseases</topic><topic>Heart failure</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Leukocytes, Mononuclear - pathology</topic><topic>MACEs</topic><topic>Male</topic><topic>Malondialdehyde</topic><topic>Medical imaging</topic><topic>Medical prognosis</topic><topic>MMP‐9</topic><topic>Nitric oxide</topic><topic>Peripheral blood</topic><topic>Peripheral circulation</topic><topic>Population</topic><topic>Progenitor cells</topic><topic>Prognosis</topic><topic>Short Communication</topic><topic>Short Communications</topic><topic>sICAM‐1</topic><topic>SOD</topic><topic>Solubility</topic><topic>Statistical analysis</topic><topic>Stem cells</topic><topic>Stem Cells - pathology</topic><topic>Studies</topic><topic>Subpopulations</topic><topic>Superoxide dismutase</topic><topic>Survival analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suárez‐Cuenca, Juan Antonio</creatorcontrib><creatorcontrib>Robledo‐Nolasco, Rogelio</creatorcontrib><creatorcontrib>Alcántara‐Meléndez, Marco Antonio</creatorcontrib><creatorcontrib>Díaz Hernández, Luis Javier</creatorcontrib><creatorcontrib>Vera‐Gómez, Eduardo</creatorcontrib><creatorcontrib>Hernández‐Patricio, Alejandro</creatorcontrib><creatorcontrib>Sánchez‐Díaz, Karla Susana</creatorcontrib><creatorcontrib>Buendía‐Gutiérrez, Juan Ariel</creatorcontrib><creatorcontrib>Contreras‐Ramos, Alejandra</creatorcontrib><creatorcontrib>Ruíz‐Hernández, Atzin Suá</creatorcontrib><creatorcontrib>Pérez‐Cabeza de Vaca, Rebeca</creatorcontrib><creatorcontrib>Mondragón‐Terán, Paul</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cellular and molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suárez‐Cuenca, Juan Antonio</au><au>Robledo‐Nolasco, Rogelio</au><au>Alcántara‐Meléndez, Marco Antonio</au><au>Díaz Hernández, Luis Javier</au><au>Vera‐Gómez, Eduardo</au><au>Hernández‐Patricio, Alejandro</au><au>Sánchez‐Díaz, Karla Susana</au><au>Buendía‐Gutiérrez, Juan Ariel</au><au>Contreras‐Ramos, Alejandra</au><au>Ruíz‐Hernández, Atzin Suá</au><au>Pérez‐Cabeza de Vaca, Rebeca</au><au>Mondragón‐Terán, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coronary circulating mononuclear progenitor cells and soluble biomarkers in the cardiovascular prognosis after coronary angioplasty</atitle><jtitle>Journal of cellular and molecular medicine</jtitle><addtitle>J Cell Mol Med</addtitle><date>2019-07</date><risdate>2019</risdate><volume>23</volume><issue>7</issue><spage>4844</spage><epage>4849</epage><pages>4844-4849</pages><issn>1582-1838</issn><eissn>1582-4934</eissn><abstract>Currently, there are no confident prognostic markers in patients with coronary artery disease (CAD) undergoing angioplasty. The present study aimed to explore whether basal coronary circulating Mononuclear Progenitor Cells (MPCs) and vascular injury biomarkers were related to development of major adverse cardiovascular events (MACEs) and may impact clinical prognosis.
Methods
The number of MPCs and soluble mediators such as IL‐1β, sICAM‐1, MMP‐9, malondialdehyde, superoxide dismutase and nitric oxide were determined in coronary and peripheral circulation. Prognostic ability for MACEs occurring at 6 months follow up was assessed by time‐to‐event and event free survival estimations.
Results
Lower coronary circulating MPCs subpopulations CD45+CD34+, CD45+CD34+CD133+CD184+, lower MMP‐9 and higher sICAM‐1 significantly associated with MACEs presentation and showed prognostic ability; while peripheral blood increase in malondialdehyde and decreased superoxide dismutase were observed in patients with MACEs.
Conclusion
Coronary concentration of biomarkers related with vascular repair, such as MPCs subpopulations and adhesion molecules, may predict MACEs and impact prognosis in patients with CAD undergoing angioplasty; whereas peripheral pro‐oxidative condition may be also associated.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>31069956</pmid><doi>10.1111/jcmm.14336</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-2098-5658</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Aged Angina pectoris Angioplasty Biomarkers Biomarkers - blood Blood pressure Cardiovascular disease Cardiovascular Diseases - blood Cardiovascular Diseases - diagnosis CD18 antigen CD34 antigen CD45 antigen Coronary artery Coronary artery disease Coronary Circulation Diabetes EPCs Female Flow cytometry Heart attacks Heart diseases Heart failure Humans Hypertension Leukocytes, Mononuclear - pathology MACEs Male Malondialdehyde Medical imaging Medical prognosis MMP‐9 Nitric oxide Peripheral blood Peripheral circulation Population Progenitor cells Prognosis Short Communication Short Communications sICAM‐1 SOD Solubility Statistical analysis Stem cells Stem Cells - pathology Studies Subpopulations Superoxide dismutase Survival analysis |
| title | Coronary circulating mononuclear progenitor cells and soluble biomarkers in the cardiovascular prognosis after coronary angioplasty |
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