A new type of silyl protecting groups in nucleoside chemistry

A new type of silyl protecting groups in nucleoside chemistry

A new type of silyl protecting group was designed and a reagent for its introduction was obtained. This reagent, 1,3--dihalo-1,1,3,3-tetraalkyldisiloxane, allows simultaneous protection of 3′-OH and 5′-OH groups of nucleoside in high yield. The properties of the new protecting group were studied and...

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Veröffentlicht in:Nucleic acids research 1978, Vol.1 (suppl-1), p.s185-s190
Hauptverfasser: Markiewicz, W.T., Wiewiórowski, M.
Format: Artikel
Sprache:eng
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Zusammenfassung:A new type of silyl protecting group was designed and a reagent for its introduction was obtained. This reagent, 1,3--dihalo-1,1,3,3-tetraalkyldisiloxane, allows simultaneous protection of 3′-OH and 5′-OH groups of nucleoside in high yield. The properties of the new protecting group were studied and some aspects of its applications are presented.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/1.suppl_1.s185