Photocontrollable mononegaviruses

Mononegaviruses are promising tools as oncolytic vectors and transgene delivery vectors for gene therapy and regenerative medicine. By using the Magnet proteins, which reversibly heterodimerize upon blue light illumination, photocontrollable mononegaviruses (measles and rabies viruses) were generate...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-06, Vol.116 (24), p.11587-11589
Hauptverfasser:	Tahara, Maino, Takishima, Yuto, Miyamoto, Shohei, Nakatsu, Yuichiro, Someya, Kenji, Sato, Moritoshi, Tani, Kenzaburo, Takeda, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences BRIEF REPORT Cell Line, Tumor DNA-Directed RNA Polymerases - genetics Expression vectors Gene therapy Genetic Therapy - methods Genetic Vectors - genetics Humans Illumination Light Measles Measles virus - genetics Mice, Inbred BALB C Mice, Nude Oncolysis Oncolytic Virotherapy - methods Oncolytic Viruses - genetics Proteins Rabies Rabies virus - genetics Regenerative medicine Transgenes - genetics Virus Replication - genetics Viruses
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Beschreibung
Zusammenfassung:	Mononegaviruses are promising tools as oncolytic vectors and transgene delivery vectors for gene therapy and regenerative medicine. By using the Magnet proteins, which reversibly heterodimerize upon blue light illumination, photocontrollable mononegaviruses (measles and rabies viruses) were generated. The Magnet proteins were inserted into the flexible domain of viral polymerase, and viruses showed strong replication and oncolytic activities only when the viral polymerases were activated by blue light illumination.
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.1906531116