Luteinizing Hormone-Releasing Hormone (LHRH) Neurons Maintained in Hypothalamic Slice Explant Cultures Exhibit a Rapid LHRH mRNA Turnover Rate

Luteinizing Hormone-Releasing Hormone (LHRH) Neurons Maintained in Hypothalamic Slice Explant Cultures Exhibit a Rapid LHRH mRNA Turnover Rate

Evidence indicates that neuropeptide gene expression is tightly coupled to biosynthesis and secretion. Moreover, rhythmic gene expression often accompanies rhythmic secretion. Luteinizing hormone-releasing hormone (LHRH) neurosecretion, which regulates gonadal function, is pulsatile, with interpulse...

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Veröffentlicht in:The Journal of neuroscience 1997-12, Vol.17 (24), p.9481-9491
Hauptverfasser: Maurer, Jennifer A, Wray, Susan
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Culture Techniques - methods
Dichlororibofuranosylbenzimidazole
Gene Expression - drug effects
Gene Expression - physiology
Gonadotropin-Releasing Hormone - analysis
Gonadotropin-Releasing Hormone - genetics
Hippocampus - cytology
Neurons - chemistry
Neurons - cytology
Neurons - physiology
Nucleic Acid Synthesis Inhibitors
Preoptic Area - cytology
Rats
RNA, Messenger - metabolism
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Zusammenfassung:Evidence indicates that neuropeptide gene expression is tightly coupled to biosynthesis and secretion. Moreover, rhythmic gene expression often accompanies rhythmic secretion. Luteinizing hormone-releasing hormone (LHRH) neurosecretion, which regulates gonadal function, is pulsatile, with interpulse intervals of approximately 1 hr and pulse decays of
ISSN:0270-6474
1529-2401
DOI:10.1523/jneurosci.17-24-09481.1997