Xpert MTB/RIF and Xpert MTB/RIF Ultra assays for active tuberculosis and rifampicin resistance in children

This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows: Primary objectives To determine the diagnostic accuracy of Xpert MTB/RIF and Xpert Ultra for a) PTB in children presumed to have tuberculosis; b) lymph node tuberculosis in children presumed to have tuberculosis; c) tuberculous meningitis in children presumed to have tuberculosis; and d) rifampicin resistance in children presumed to have tuberculosis. For tuberculosis detection, the role of the index tests would be a replacement for standard practice. For rifampicin resistance detection, the role of the index tests would be an initial replacement test for culture‐based drug susceptibility testing.