Cyclic nucleotide signaling in sensory neuron hyperexcitability and chronic pain after nerve injury

Cyclic nucleotide signaling in sensory neuron hyperexcitability and chronic pain after nerve injury

Highlights•Activation of cAMP-PKA and cGMP-PKG pathways contributes to injury-induced sensory neuron hyperexcitability.•Activation of cAMP and cGMP contributes to the development of bone cancer pain.•PAR2 activation mediates injury-induced cAMP-dependent sensory neuron hyperexcitability.

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Veröffentlicht in:Neurobiology of pain 2019-08, Vol.6, p.100028-100028, Article 100028
Hauptverfasser: Li, Ze-Hua, Cui, Dong, Qiu, Cheng-Jie, Song, Xue-Jun
Format: Artikel
Sprache:eng
Schlagworte:
Pain Medicine
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Zusammenfassung:Highlights•Activation of cAMP-PKA and cGMP-PKG pathways contributes to injury-induced sensory neuron hyperexcitability.•Activation of cAMP and cGMP contributes to the development of bone cancer pain.•PAR2 activation mediates injury-induced cAMP-dependent sensory neuron hyperexcitability.
ISSN:2452-073X
2452-073X
DOI:10.1016/j.ynpai.2019.100028