Direct oral anticoagulants versus vitamin K antagonists after recent ischemic stroke in patients with atrial fibrillation

Objective We compared outcomes after treatment with direct oral anticoagulants (DOACs) and vitamin K antagonists (VKAs) in patients with atrial fibrillation (AF) and a recent cerebral ischemia. Methods We conducted an individual patient data analysis of seven prospective cohort studies. We included...

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Veröffentlicht in:	Annals of neurology 2019-06, Vol.85 (6), p.823-834
Hauptverfasser:	Seiffge, David J., Paciaroni, Maurizio, Wilson, Duncan, Koga, Masatoshi, Macha, Kosmas, Cappellari, Manuel, Schaedelin, Sabine, Shakeshaft, Clare, Takagi, Masahito, Tsivgoulis, Georgios, Bonetti, Bruno, Kallmünzer, Bernd, Arihiro, Shoji, Alberti, Andrea, Polymeris, Alexandros A., Ambler, Gareth, Yoshimura, Sohei, Venti, Michele, Bonati, Leo H., Muir, Keith W., Yamagami, Hiroshi, Thilemann, Sebastian, Altavilla, Riccardo, Peters, Nils, Inoue, Manabu, Bobinger, Tobias, Agnelli, Giancarlo, Brown, Martin M., Sato, Shoichiro, Acciarresi, Monica, Jager, Hans Rolf, Bovi, Paolo, Schwab, Stefan, Lyrer, Philippe, Caso, Valeria, Toyoda, Kazunori, Werring, David J., Engelter, Stefan T., De Marchis, Gian Marco
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Aged Aged, 80 and over Antagonists Anticoagulants Anticoagulants - administration & dosage Atrial Fibrillation - diagnosis Atrial Fibrillation - drug therapy Atrial Fibrillation - epidemiology Brain Ischemia - diagnosis Brain Ischemia - drug therapy Brain Ischemia - epidemiology Cardiac arrhythmia Cohort Studies Confidence intervals Data analysis Female Fibrillation Follow-Up Studies Hazards Hemorrhage Humans Ischemia Male Mortality Patients Prospective Studies Regression analysis Regression models Risk factors Risk management Statistical analysis Stroke Stroke - diagnosis Stroke - drug therapy Stroke - epidemiology Vitamin K Vitamin K - antagonists & inhibitors
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Zusammenfassung:	Objective We compared outcomes after treatment with direct oral anticoagulants (DOACs) and vitamin K antagonists (VKAs) in patients with atrial fibrillation (AF) and a recent cerebral ischemia. Methods We conducted an individual patient data analysis of seven prospective cohort studies. We included patients with AF and a recent cerebral ischemia (
ISSN:	0364-5134 1531-8249
DOI:	10.1002/ana.25489