The unrecognized burden of cardiovascular risk factors in women newly diagnosed with endometrial cancer: A prospective case control study

•CVD risk was measured in a prospective study of 150 EC patients and 746 controls.•EC patients had significantly more CVD risk factors than other women.•Most CVD risk factors were either unrecognized or inadequately treated.•EC patients had a significantly higher 10-year risk of CVD (QRISK2) than controls.•Identifying and treating CVD risk factors could improve outcomes for EC survivors. Cardiovascular disease is a major cause of death in endometrial cancer survivors. The aim of this study was to determine whether women newly diagnosed with endometrial cancer have a higher prevalence of cardiovascular risk factors than the general population. The prevalence of adequately treated and unrecognized/inadequately treated cardiovascular risk factors and the corresponding 10-year cardiovascular risk by QRISK2 score was measured in 150 consecutive women undergoing primary treatment for endometrioid endometrial cancer in the North West of England, and 746 age and ethnicity-matched control women from the Health Survey for England 2014. Women with endometrial cancer had higher proportions of obesity (BMI≥30 60.7% vs. 32.4%, p